WormBase Tree Display for Gene: WBGene00006436
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| WBGene00006436 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
| Identity | Version | 4 | |||||||
| Name | CGC_name | ttn-1 | Person_evidence | WBPerson56 | |||||
| Sequence_name | W06H8.8 | ||||||||
| Molecular_name (43) | |||||||||
| Other_name | tag-7 | Curator_confirmed | WBPerson2970 | ||||||
| tag-211 | Curator_confirmed | WBPerson2970 | |||||||
| tag-58 | Person_evidence | WBPerson201 | |||||||
| Y38B5A.a | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y38B5A.b | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_W06H8.8 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ttn-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 May 2004 14:21:37 | WBPerson1971 | Event | Acquires_merge | WBGene00021069 | ||||
| 3 | 07 Jul 2005 09:36:06 | WBPerson1983 | Event | Acquires_merge | WBGene00006401 | ||||
| 4 | 13 Dec 2005 14:47:30 | WBPerson2970 | Name_change | CGC_name | ttn-1 | ||||
| Other_name | tag-58 | ||||||||
| Acquires_merge | WBGene00006401 | ||||||||
| WBGene00021069 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ttn | ||||||||
| Allele (927) | |||||||||
| Strain | WBStrain00035550 | ||||||||
| WBStrain00035671 | |||||||||
| WBStrain00035980 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (28) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | ttn-1, through multiple splicing, encodes at least six protein isoformsthat are orthologs of titin (OMIM:188840, mutated in cardiomyopathy ortibial muscular dystrophy), with the three largest isoforms being 2.2MDa, 1.2 MDa and 301 kDa; TTN-1 isoforms are expressed in body wall andvulval muscle, localized to the centers of I-bands, with the two largestisoforms expressed in all muscles except pharyngeal; the largest TTN-1isoform contains 56 Ig domains, 11 FnIII domains, a twitchin-likeprotein kinase domain, a domain similar to the elastic PEVK domain ofvertebrate titin, 96 tandem copies of a 16-residue motif predicted tocomprise a coiled-coil domain, and two other short multiply repeatedmotifs; the TTN-1 kinase domain is catalytically active, and itsactivity is quantitatively regulated by alternative splicing of anadjacent autoinhibitory domain; TTN-1 is mislocalized in analpha-actinin mutant (atn-1[ok84]); ttn-1 is transcribed from at leasttwo promoters, and its transcription is stimulated by NFI-1. | Paper_evidence | WBPaper00005546 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00026912 | |||||||||
| WBPaper00027070 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity and myosin binding activity. Predicted to be involved in phosphorylation. Located in A band and I band. Expressed in muscle cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS (14) | ||||||||
| Corresponding_CDS_history | W06H8.8a:wp262 | ||||||||
| W06H8.8b:wp262 | |||||||||
| W06H8.8d:wp262 | |||||||||
| W06H8.8e:wp262 | |||||||||
| W06H8.8f:wp262 | |||||||||
| W06H8.8g:wp262 | |||||||||
| Corresponding_transcript (15) | |||||||||
| Other_sequence (76) | |||||||||
| Associated_feature (48) | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Chronogram625 | ||||||||
| Expr2286 | |||||||||
| Expr6846 | |||||||||
| Expr9017 | |||||||||
| Expr1032615 | |||||||||
| Expr1158464 | |||||||||
| Expr2017574 | |||||||||
| Expr2035713 | |||||||||
| Drives_construct | WBCnstr00002629 | ||||||||
| Antibody | WBAntibody00000570 | ||||||||
| WBAntibody00000571 | |||||||||
| WBAntibody00002134 | |||||||||
| WBAntibody00002135 | |||||||||
| WBAntibody00002136 | |||||||||
| Microarray_results (80) | |||||||||
| Expression_cluster (261) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | V | Position | -0.235725 | Error | 0.011128 | |||
| Positive | Positive_clone | W06H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
