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WormBase Tree Display for Gene: WBGene00002011

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Name Class

WBGene00002011EvidenceCGC_data_submission
SMapS_parentSequenceC14B9
IdentityVersion1
NameCGC_namehsp-12.2Person_evidenceWBPerson36
Sequence_nameC14B9.1
Molecular_nameC14B9.1
C14B9.1.1
CE00072
Other_nameCELE_C14B9.1Accession_evidenceNDBBX284603
Public_namehsp-12.2
DB_infoDatabaseAceViewgene3J229
WormQTLgeneWBGene00002011
WormFluxgeneWBGene00002011
NDBlocus_tagCELE_C14B9.1
PanthergeneCAEEL|WormBase=WBGene00002011|UniProtKB=P34328
familyPTHR45640
NCBIgene176148
RefSeqproteinNM_066375.8
SwissProtUniProtAccP34328
UniProt_GCRPUniProtAccP34328
OMIMgene123580
123590
602195
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhsp
Allele (18)
Legacy_informationsmall heat shock protein
StrainWBStrain00033286
RNASeq_FPKM (74)
GO_annotation00041637
00041638
00041639
00041640
00041641
00041642
00041643
Ortholog (41)
Paralog (17)
Structured_descriptionConcise_descriptionhsp-12.2 encodes a small heat-shock protein that forms heterotetramerswith HSP-12.3 and has no chaperone-like activity; structurally, HSP-12.2is mostly a beta-sheet; at least one HSP-12 (which may or may not beHSP-12.2) is ubiquitously expressed in L1 larvae, and later expressed inadult spermatids (and perhaps spermatocytes), and some adult vulvalcells.Paper_evidenceWBPaper00003194
WBPaper00004387
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated31 Jan 2007 00:00:00
Automated_descriptionEnables heat shock protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2F; cataract (multiple); and myofibrillar myopathy (multiple). Is an ortholog of human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (11)
Molecular_infoCorresponding_CDSC14B9.1
Corresponding_transcriptC14B9.1.1
Other_sequence (77)
Associated_featureWBsf645389
WBsf645390
WBsf659231
WBsf993251
WBsf993252
WBsf1015363
WBsf225354
WBsf225355
Experimental_infoRNAi_resultWBRNAi00040502Inferred_automaticallyRNAi_primary
WBRNAi00010731Inferred_automaticallyRNAi_primary
WBRNAi00028878Inferred_automaticallyRNAi_primary
WBRNAi00106377Inferred_automaticallyRNAi_primary
WBRNAi00005756Inferred_automaticallyRNAi_primary
WBRNAi00040503Inferred_automaticallyRNAi_primary
WBRNAi00006681Inferred_automaticallyRNAi_primary
WBRNAi00005761Inferred_automaticallyRNAi_primary
WBRNAi00076123Inferred_automaticallyRNAi_primary
WBRNAi00040501Inferred_automaticallyRNAi_primary
Expr_patternExpr15513
Expr1017917
Expr1031174
Expr1144567
Expr2012613
Expr2030849
Drives_constructWBCnstr00036524
WBCnstr00042204
Construct_productWBCnstr00036524
WBCnstr00042204
AntibodyWBAntibody00003011
Microarray_results (20)
Expression_cluster (196)
Interaction (68)
Map_infoMapIIIPosition-0.376106Error0.000134
PositivePositive_cloneC14B9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (11)
RemarkSequence connection from [Kokke BPA, de Jong WW]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene