WormBase Tree Display for Gene: WBGene00000802
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| WBGene00000802 | SMap | S_parent | Sequence | Y38A10A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | crt-1 | |||||||
| Sequence_name | Y38A10A.5 | ||||||||
| Molecular_name | Y38A10A.5 | ||||||||
| Y38A10A.5.1 | |||||||||
| CE21562 | |||||||||
| Other_name | CELE_Y38A10A.5 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | crt-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | crt | ||||||||
| Allele (34) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted 395 aa calreticulin(61% identity to mouse calreticulin). [Smith 1992] | ||||||||
| Strain | WBStrain00023525 | ||||||||
| WBStrain00031729 | |||||||||
| WBStrain00040781 | |||||||||
| WBStrain00040782 | |||||||||
| WBStrain00040783 | |||||||||
| WBStrain00040784 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00000567 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | crt-1 encodes an ortholog of calreticulin (a calcium-binding molecularchaperone of the endoplasmic reticulum); crt-1 is dispensable forviability, but required for normal sperm development, male matingefficiency, some forms of necrotic cell death, and hermaphrodite fertilityat high temperatures (which may reflect a stress response); crt-1expression is induced by stress; CRT-1 protein binds Ca(2+) and cansuppress heat-induced protein aggregation in vitro; crt-1(bz29) andcrt-1(bz30) mutants suppress necrotic cell death induced either bymec-4(d) or by a constitutively activated Gas subunit; crt-1(bz29);crt-1's suppression of necrosis is itself partly reversed by thapsigargin,which enhances calcium release from the endoplasmic reticulum;crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have havereduced broods at 25 deg. C.; crt-1(jh101) mutants are slightly shorterthan normal and have defective sperm; CRT-1 and ITR-1 serve partlyredundant functions in vivo, since crt-1;itr-1(sa73) are highly infertileand slow-growing with greatly slowed defecation; a number of proteins,notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutantsand crt-1(jh101);cnx-1(nr2009) double mutants. | Paper_evidence | WBPaper00004858 | |||||
| WBPaper00004880 | |||||||||
| WBPaper00027024 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 21 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00053621 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Mar 2019 00:00:00 | ||||||||
| Potential_model (22) | |||||||||
| Models_disease_asserted | WBDOannot00000639 | ||||||||
| Molecular_info | Corresponding_CDS | Y38A10A.5 | |||||||
| Corresponding_transcript | Y38A10A.5.1 | ||||||||
| Other_sequence (306) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000682 | ||||||||
| WBCnstr00010817 | |||||||||
| WBCnstr00037266 | |||||||||
| Construct_product | WBCnstr00006884 | ||||||||
| WBCnstr00037266 | |||||||||
| Regulate_expr_cluster | WBPaper00064957:crt-1(jvp1)_downregulated | ||||||||
| WBPaper00064957:crt-1(jvp1)_upregulated | |||||||||
| WBPaper00064957:crt-1(knu358)_downregulated | |||||||||
| WBPaper00064957:crt-1(knu358)_upregulated | |||||||||
| Antibody | WBAntibody00000408 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (193) | |||||||||
| Interaction (116) | |||||||||
| WBProcess | WBbiopr:00000046 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | V | Position | -0.354153 | Error | 0.004638 | |||
| Positive | Positive_clone | Y38A10A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZL188 | |||||||||
| Mapping_data | Multi_point | 4240 | |||||||
| 4964 | |||||||||
| 5324 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (72) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
