WormBase Tree Display for Gene: WBGene00000567
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| WBGene00000567 | SMap | S_parent | Sequence | ZK632 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cnx-1 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | ZK632.6 | ||||||||
| Molecular_name | ZK632.6a | ||||||||
| ZK632.6a.1 | |||||||||
| CE00423 | |||||||||
| ZK632.6b | |||||||||
| CE49246 | |||||||||
| ZK632.6b.1 | |||||||||
| Other_name | CELE_ZK632.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cnx-1 | ||||||||
| DB_info | Database | AceView | gene | 3K904 | |||||
| WormQTL | gene | WBGene00000567 | |||||||
| WormFlux | gene | WBGene00000567 | |||||||
| NDB | locus_tag | CELE_ZK632.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000567|UniProtKB=P34652 | |||||||
| family | PTHR11073 | ||||||||
| NCBI | gene | 176390 | |||||||
| RefSeq | protein | NM_001306672.3 | |||||||
| NM_066775.7 | |||||||||
| SwissProt | UniProtAcc | P34652 | |||||||
| TrEMBL | UniProtAcc | V6CLE5 | |||||||
| UniProt_GCRP | UniProtAcc | P34652 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cnx | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00029109 | ||||||||
| WBStrain00029111 | |||||||||
| WBStrain00036885 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000802 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER); CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis; in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development; cnx-1 activity is also required for maintaining viability in response to ER stress; in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death; CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions; post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail; antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum; in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein. | Paper_evidence | WBPaper00004880 | |||||
| WBPaper00026928 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Jul 2006 00:00:00 | ||||||||
| Automated_description | Enables calcium ion binding activity. Involved in IRE1-mediated unfolded protein response and response to heat. Located in perinuclear region of cytoplasm. Expressed in copulatory spicule; excretory cell; nervous system; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human CANX (calnexin) and CLGN (calmegin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1473) | ||||
| Molecular_info | Corresponding_CDS | ZK632.6a | |||||||
| ZK632.6b | |||||||||
| Corresponding_transcript | ZK632.6a.1 | ||||||||
| ZK632.6b.1 | |||||||||
| Other_sequence (72) | |||||||||
| Associated_feature | WBsf651409 | ||||||||
| WBsf651410 | |||||||||
| WBsf651411 | |||||||||
| WBsf667330 | |||||||||
| WBsf993809 | |||||||||
| WBsf227373 | |||||||||
| WBsf227374 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00080518 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022092 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006082 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065643 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114759 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00002346 | ||||||||
| WBCnstr00012251 | |||||||||
| WBCnstr00037447 | |||||||||
| WBCnstr00040125 | |||||||||
| WBCnstr00040128 | |||||||||
| WBCnstr00040702 | |||||||||
| Construct_product | WBCnstr00037447 | ||||||||
| WBCnstr00040125 | |||||||||
| Antibody | WBAntibody00001028 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | III | Position | 1.09307 | Error | 0.005148 | |||
| Positive | Positive_clone | ZK632 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4231 | |||||||
| 5015 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
