| WBGene00000567 | SMap | S_parent | Sequence | ZK632 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cnx-1 | Person_evidence | WBPerson1122 |
| | | Sequence_name | ZK632.6 |
| | | Molecular_name | ZK632.6a |
| | | | ZK632.6a.1 |
| | | | CE00423 |
| | | | ZK632.6b |
| | | | CE49246 |
| | | | ZK632.6b.1 |
| | | Other_name | CELE_ZK632.6 | Accession_evidence | NDB | BX284603 |
| | | Public_name | cnx-1 |
| | DB_info | Database | AceView | gene | 3K904 |
| | | | WormQTL | gene | WBGene00000567 |
| | | | WormFlux | gene | WBGene00000567 |
| | | | NDB | locus_tag | CELE_ZK632.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000567|UniProtKB=P34652 |
| | | | | family | PTHR11073 |
| | | | NCBI | gene | 176390 |
| | | | RefSeq | protein | NM_001306672.3 |
| | | | | | NM_066775.7 |
| | | | SwissProt | UniProtAcc | P34652 |
| | | | TrEMBL | UniProtAcc | V6CLE5 |
| | | | UniProt_GCRP | UniProtAcc | P34652 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cnx |
| | Allele (37) |
| | Strain | WBStrain00029109 |
| | | WBStrain00029111 |
| | | WBStrain00036885 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (43) |
| | Paralog | WBGene00000802 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER); CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis; in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development; cnx-1 activity is also required for maintaining viability in response to ER stress; in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death; CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions; post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail; antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum; in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein. | Paper_evidence | WBPaper00004880 |
| | | | | | WBPaper00026928 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 28 Jul 2006 00:00:00 |
| | | Automated_description | Enables calcium ion binding activity. Involved in IRE1-mediated unfolded protein response and response to heat. Located in perinuclear region of cytoplasm. Expressed in copulatory spicule; excretory cell; nervous system; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human CANX (calnexin) and CLGN (calmegin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1473) |
| Molecular_info | Corresponding_CDS | ZK632.6a |
| | | ZK632.6b |
| | Corresponding_transcript | ZK632.6a.1 |
| | | ZK632.6b.1 |
| | Other_sequence (72) |
| | Associated_feature | WBsf651409 |
| | | WBsf651410 |
| | | WBsf651411 |
| | | WBsf667330 |
| | | WBsf993809 |
| | | WBsf227373 |
| | | WBsf227374 |
| Experimental_info | RNAi_result | WBRNAi00080518 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022092 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059574 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00006082 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065643 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076890 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00114759 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00002346 |
| | | WBCnstr00012251 |
| | | WBCnstr00037447 |
| | | WBCnstr00040125 |
| | | WBCnstr00040128 |
| | | WBCnstr00040702 |
| | Construct_product | WBCnstr00037447 |
| | | WBCnstr00040125 |
| | Antibody | WBAntibody00001028 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00029359_1124 |
| | | WBPaper00029359_1141 |
| | | WBPaper00029359_1227 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1351 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1525 |
| | | WBPaper00029359_1604 |
| | | WBPaper00029359_1682 |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00050015:ifg-1(RNAi)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056034:pals-25(jy9)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:Excretory_cell |
| | | WBPaper00061340:RIV |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:uggt-1_21889-tag-320_20312 |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00064992:Eugenol_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_7 |
| | | WBPaper00025032:cluster_32 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(53_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc6390]:herm_sex-enriched |
| | Interaction (66) |
| Map_info | Map | III | Position | 1.09307 | Error | 0.005148 |
| | Positive | Positive_clone | ZK632 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4231 |
| | | | 5015 |
| | Pseudo_map_position |
| Reference (24) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
