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WormBase Tree Display for Gene: WBGene00000802

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Name Class

WBGene00000802SMapS_parentSequenceY38A10A
IdentityVersion1
NameCGC_namecrt-1
Sequence_nameY38A10A.5
Molecular_nameY38A10A.5
Y38A10A.5.1
CE21562
Other_nameCELE_Y38A10A.5Accession_evidenceNDBBX284605
Public_namecrt-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcrt
Allele (34)
Legacy_information[C.elegansII] NMK. Encodes predicted 395 aa calreticulin(61% identity to mouse calreticulin). [Smith 1992]
StrainWBStrain00023525
WBStrain00031729
WBStrain00040781
WBStrain00040782
WBStrain00040783
WBStrain00040784
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (47)
ParalogWBGene00000567Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptioncrt-1 encodes an ortholog of calreticulin (a calcium-binding molecularchaperone of the endoplasmic reticulum); crt-1 is dispensable forviability, but required for normal sperm development, male matingefficiency, some forms of necrotic cell death, and hermaphrodite fertilityat high temperatures (which may reflect a stress response); crt-1expression is induced by stress; CRT-1 protein binds Ca(2+) and cansuppress heat-induced protein aggregation in vitro; crt-1(bz29) andcrt-1(bz30) mutants suppress necrotic cell death induced either bymec-4(d) or by a constitutively activated Gas subunit; crt-1(bz29);crt-1's suppression of necrosis is itself partly reversed by thapsigargin,which enhances calcium release from the endoplasmic reticulum;crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have havereduced broods at 25 deg. C.; crt-1(jh101) mutants are slightly shorterthan normal and have defective sperm; CRT-1 and ITR-1 serve partlyredundant functions in vivo, since crt-1;itr-1(sa73) are highly infertileand slow-growing with greatly slowed defecation; a number of proteins,notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutantsand crt-1(jh101);cnx-1(nr2009) double mutants.Paper_evidenceWBPaper00004858
WBPaper00004880
WBPaper00027024
Curator_confirmedWBPerson567
Date_last_updated21 Aug 2006 00:00:00
Automated_descriptionEnables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14330Homo sapiensPaper_evidenceWBPaper00053621
Curator_confirmedWBPerson324
Date_last_updated04 Mar 2019 00:00:00
Potential_model (22)
Models_disease_assertedWBDOannot00000639
Molecular_infoCorresponding_CDSY38A10A.5
Corresponding_transcriptY38A10A.5.1
Other_sequence (306)
Associated_feature (15)
Experimental_infoRNAi_result (25)
Expr_pattern (12)
Drives_constructWBCnstr00000682
WBCnstr00010817
WBCnstr00037266
Construct_productWBCnstr00006884
WBCnstr00037266
Regulate_expr_clusterWBPaper00064957:crt-1(jvp1)_downregulated
WBPaper00064957:crt-1(jvp1)_upregulated
WBPaper00064957:crt-1(knu358)_downregulated
WBPaper00064957:crt-1(knu358)_upregulated
AntibodyWBAntibody00000408
Microarray_results (24)
Expression_cluster (193)
InteractionWBInteraction000001417
WBInteraction000001419
WBInteraction000001420
WBInteraction000001843
WBInteraction000002013
WBInteraction000004658
WBInteraction000005528
WBInteraction000005529
WBInteraction000005530
WBInteraction000028946
WBInteraction000029424
WBInteraction000030188
WBInteraction000030189
WBInteraction000030190
WBInteraction000030191
WBInteraction000047673
WBInteraction000051801
WBInteraction000051808
WBInteraction000051815
WBInteraction000051816
WBInteraction000051819
WBInteraction000052755
WBInteraction000157923
WBInteraction000159743
WBInteraction000160281
WBInteraction000162259
WBInteraction000162267
WBInteraction000162370
WBInteraction000162427
WBInteraction000162428
WBInteraction000162664
WBInteraction000162668
WBInteraction000165892
WBInteraction000166060
WBInteraction000166438
WBInteraction000167678
WBInteraction000167680
WBInteraction000167685
WBInteraction000167687
WBInteraction000167689
WBInteraction000167695
WBInteraction000167828
WBInteraction000173605
WBInteraction000187788
WBInteraction000195861
WBInteraction000217899
WBInteraction000218144
WBInteraction000228197
WBInteraction000238736
WBInteraction000248182
WBInteraction000256353
WBInteraction000310345
WBInteraction000335516
WBInteraction000337733
WBInteraction000346735
WBInteraction000361430
WBInteraction000361553
WBInteraction000367930
WBInteraction000416441
WBInteraction000430569
WBInteraction000431353
WBInteraction000432223
WBInteraction000455333
WBInteraction000500988
WBInteraction000501716
WBInteraction000502119
WBInteraction000502301
WBInteraction000502302
WBInteraction000502981
WBInteraction000502982
WBInteraction000502983
WBInteraction000502984
WBInteraction000502985
WBInteraction000504662
WBInteraction000517097
WBInteraction000522002
WBInteraction000534936
WBInteraction000536460
WBInteraction000536547
WBInteraction000536747
WBInteraction000536757
WBInteraction000536759
WBInteraction000536763
WBInteraction000536764
WBInteraction000536766
WBInteraction000536767
WBInteraction000536797
WBInteraction000536802
WBInteraction000539794
WBInteraction000539845
WBInteraction000540930
WBInteraction000549891
WBInteraction000550880
WBInteraction000550945
WBInteraction000553117
WBInteraction000554021
WBInteraction000555033
WBInteraction000561305
WBInteraction000562104
WBInteraction000562573
WBInteraction000563251
WBInteraction000567983
WBInteraction000569629
WBInteraction000570799
WBInteraction000571514
WBInteraction000571524
WBInteraction000572172
WBInteraction000572663
WBInteraction000572882
WBInteraction000573377
WBInteraction000577518
WBInteraction000579532
WBInteraction000579923
WBInteraction000582527
WBInteraction000582917
WBInteraction000585840
WBProcessWBbiopr:00000046
WBbiopr:00000079
Map_infoMapVPosition-0.354153Error0.004638
PositivePositive_cloneY38A10AInferred_automaticallyFrom sequence, transcript, pseudogene data
ZL188
Mapping_dataMulti_point4240
4964
5324
Pseudo_map_position
Reference (72)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene