WormBase Tree Display for Gene: WBGene00006434
expand all nodes | collapse all nodes | view schema
| WBGene00006434 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F09E5 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | prdx-2 | Paper_evidence | WBPaper00006517 | |||||
| Sequence_name | F09E5.15 | ||||||||
| Molecular_name | F09E5.15a | ||||||||
| F09E5.15a.1 | |||||||||
| CE32361 | |||||||||
| F09E5.15b | |||||||||
| CE41559 | |||||||||
| F09E5.15c | |||||||||
| CE50863 | |||||||||
| F09E5.15b.1 | |||||||||
| F09E5.15c.1 | |||||||||
| Other_name | ceprx2 | Paper_evidence | WBPaper00006517 | ||||||
| tag-56 | CGC_data_submission | ||||||||
| CELE_F09E5.15 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | prdx-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 13 Dec 2004 10:52:32 | WBPerson2970 | Name_change | CGC_name | prdx-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | prdx | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00035650 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Contained_in_operon | CEOP2172 | ||||||||
| CEOP2745 | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00011110 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00021401 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | prdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants. | Paper_evidence | WBPaper00032399 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Dec 2008 00:00:00 | ||||||||
| Automated_description | Enables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) | ||||
| DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) | ||||||
| DOID:0050715 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9352) | ||||||
| Molecular_info | Corresponding_CDS | F09E5.15a | |||||||
| F09E5.15b | |||||||||
| F09E5.15c | |||||||||
| Corresponding_CDS_history | F09E5.15:wp182 | ||||||||
| Corresponding_transcript | F09E5.15a.1 | ||||||||
| F09E5.15b.1 | |||||||||
| F09E5.15c.1 | |||||||||
| Other_sequence (484) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr2948 | ||||||||
| Expr2949 | |||||||||
| Expr5699 | |||||||||
| Expr8393 | |||||||||
| Expr12198 | |||||||||
| Expr1024080 | |||||||||
| Expr1032614 | |||||||||
| Expr1148092 | |||||||||
| Expr2015087 | |||||||||
| Expr2033324 | |||||||||
| Drives_construct | WBCnstr00003077 | ||||||||
| WBCnstr00011033 | |||||||||
| WBCnstr00020592 | |||||||||
| WBCnstr00034358 | |||||||||
| Construct_product | WBCnstr00005484 | ||||||||
| WBCnstr00011033 | |||||||||
| WBCnstr00020592 | |||||||||
| WBCnstr00034358 | |||||||||
| Antibody | WBAntibody00000736 | ||||||||
| WBAntibody00001484 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (165) | |||||||||
| Interaction (177) | |||||||||
| Anatomy_function | WBbtf0939 | ||||||||
| WBbtf0940 | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000055 | |||||||||
| Map_info | Map | II | Position | -1.78616 | Error | 0.000241 | |||
| Positive | Positive_clone | F09E5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4588 | |||||||
| Pseudo_map_position | |||||||||
| Reference (38) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
