| WBGene00006434 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F09E5 |
| Identity | Version | 2 |
| | Name | CGC_name | prdx-2 | Paper_evidence | WBPaper00006517 |
| | | Sequence_name | F09E5.15 |
| | | Molecular_name | F09E5.15a |
| | | | F09E5.15a.1 |
| | | | CE32361 |
| | | | F09E5.15b |
| | | | CE41559 |
| | | | F09E5.15c |
| | | | CE50863 |
| | | | F09E5.15b.1 |
| | | | F09E5.15c.1 |
| | | Other_name | ceprx2 | Paper_evidence | WBPaper00006517 |
| | | | tag-56 | CGC_data_submission |
| | | | CELE_F09E5.15 | Accession_evidence | NDB | BX284602 |
| | | Public_name | prdx-2 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 13 Dec 2004 10:52:32 | WBPerson2970 | Name_change | CGC_name | prdx-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | prdx |
| | Allele (20) |
| | Strain | WBStrain00035650 |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Contained_in_operon | CEOP2172 |
| | | CEOP2745 |
| | Ortholog (43) |
| | Paralog | WBGene00011110 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00021401 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | prdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants. | Paper_evidence | WBPaper00032399 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 10 Dec 2008 00:00:00 |
| | | Automated_description | Enables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) |
| | | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) |
| | | DOID:0050715 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9352) |
| Molecular_info | Corresponding_CDS | F09E5.15a |
| | | F09E5.15b |
| | | F09E5.15c |
| | Corresponding_CDS_history | F09E5.15:wp182 |
| | Corresponding_transcript | F09E5.15a.1 |
| | | F09E5.15b.1 |
| | | F09E5.15c.1 |
| | Other_sequence (484) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (14) |
| | Expr_pattern | Expr2948 |
| | | Expr2949 |
| | | Expr5699 |
| | | Expr8393 |
| | | Expr12198 |
| | | Expr1024080 |
| | | Expr1032614 |
| | | Expr1148092 |
| | | Expr2015087 |
| | | Expr2033324 |
| | Drives_construct | WBCnstr00003077 |
| | | WBCnstr00011033 |
| | | WBCnstr00020592 |
| | | WBCnstr00034358 |
| | Construct_product | WBCnstr00005484 |
| | | WBCnstr00011033 |
| | | WBCnstr00020592 |
| | | WBCnstr00034358 |
| | Antibody | WBAntibody00000736 |
| | | WBAntibody00001484 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00026640:Development_Group_I |
| | | WBPaper00028360:Phospho-Sulfo-Modified_proteins |
| | | WBPaper00031674:feh-1(gb561)(RNAi)_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035963:S.aureus_1h_downregulated |
| | | WBPaper00035963:S.aureus_8h_downregulated |
| | | WBPaper00035963:S.aureus_24h_downregulated |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037963:ife-1(ok1978)_downregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040446:insoluble_protein |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044427:lbp-5(tm1618)_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050636:aging_regulated_insoluble_protein |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059254:WAGO-1_interacting |
| | | WBPaper00059334:SACY-1_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061040:FW1256_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ASI |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:Excretory_duct_and_pore |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parents_of_U_F_B_DVA |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061340:Parent_of_tail_spike_and_hyp10 |
| | | WBPaper00061340:Y |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:F45H10.2-R53.4_21676 |
| | | WBPaper00061651:ASG_enriched |
| | | WBPaper00061651:AWB_enriched |
| | | WBPaper00061651:AWC_ON_enriched |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:I2_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PHB_enriched |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061651:RIM_enriched |
| | | WBPaper00062002:Day4-adult_secretome |
| | | WBPaper00062056:lin-37(n758)_downregulated |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064201:SNA-1_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4386_cluster_1_4 |
| | | WBPaper00025032:cluster_3 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (177) |
| | Anatomy_function | WBbtf0939 |
| | | WBbtf0940 |
| | WBProcess | WBbiopr:00000001 |
| | | WBbiopr:00000055 |
| Map_info | Map | II | Position | -1.78616 | Error | 0.000241 |
| | Positive | Positive_clone | F09E5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4588 |
| | Pseudo_map_position |
| Reference (38) |
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
