WormBase Tree Display for Gene: WBGene00006434
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WBGene00006434 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F09E5 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | prdx | ||||||
Allele (20) | |||||||
Strain | WBStrain00035650 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (29) | |||||||
Contained_in_operon | CEOP2172 | ||||||
CEOP2745 | |||||||
Ortholog (43) | |||||||
Paralog | WBGene00011110 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00021401 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | prdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants. | Paper_evidence | WBPaper00032399 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 10 Dec 2008 00:00:00 | ||||||
Automated_description | Enables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) | ||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9353) | ||||
DOID:0050715 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9352) | ||||
Molecular_info | Corresponding_CDS | F09E5.15a | |||||
F09E5.15b | |||||||
F09E5.15c | |||||||
Corresponding_CDS_history | F09E5.15:wp182 | ||||||
Corresponding_transcript | F09E5.15a.1 | ||||||
F09E5.15b.1 | |||||||
F09E5.15c.1 | |||||||
Other_sequence (484) | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr2948 | ||||||
Expr2949 | |||||||
Expr5699 | |||||||
Expr8393 | |||||||
Expr12198 | |||||||
Expr1024080 | |||||||
Expr1032614 | |||||||
Expr1148092 | |||||||
Expr2015087 | |||||||
Expr2033324 | |||||||
Drives_construct | WBCnstr00003077 | ||||||
WBCnstr00011033 | |||||||
WBCnstr00020592 | |||||||
WBCnstr00034358 | |||||||
Construct_product | WBCnstr00005484 | ||||||
WBCnstr00011033 | |||||||
WBCnstr00020592 | |||||||
WBCnstr00034358 | |||||||
Antibody | WBAntibody00000736 | ||||||
WBAntibody00001484 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (165) | |||||||
Interaction (177) | |||||||
Anatomy_function | WBbtf0939 | ||||||
WBbtf0940 | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000055 | |||||||
Map_info | Map | II | Position | -1.78616 | Error | 0.000241 | |
Positive | Positive_clone | F09E5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4588 | |||||
Pseudo_map_position | |||||||
Reference (38) | |||||||
Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |