WormBase Tree Display for Gene: WBGene00018892
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| WBGene00018892 | SMap | S_parent | Sequence | F55F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | cir-1 | Person_evidence | WBPerson502 | |||||
| Sequence_name | F55F8.4 | ||||||||
| Molecular_name | F55F8.4 | ||||||||
| F55F8.4.1 | |||||||||
| CE11194 | |||||||||
| F55F8.4.2 | |||||||||
| Other_name | tag-326 | ||||||||
| F55F8.i | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_F55F8.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | cir-1 | ||||||||
| DB_info | Database | AceView | gene | 1G222 | |||||
| WormQTL | gene | WBGene00018892 | |||||||
| WormFlux | gene | WBGene00018892 | |||||||
| NDB | locus_tag | CELE_F55F8.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018892|UniProtKB=G5EBE3 | |||||||
| family | PTHR13151 | ||||||||
| NCBI | gene | 172225 | |||||||
| RefSeq | protein | NM_059253.5 | |||||||
| TREEFAM | TREEFAM_ID | TF317567 | |||||||
| TrEMBL | UniProtAcc | G5EBE3 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBE3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag | ||||
| 3 | 22 May 2006 16:58:29 | WBPerson2970 | Name_change | CGC_name | cir-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cir | ||||||||
| Allele (22) | |||||||||
| Strain | WBStrain00036265 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00009359 | ||||||||
| 00009360 | |||||||||
| 00009361 | |||||||||
| 00009362 | |||||||||
| 00009363 | |||||||||
| 00009364 | |||||||||
| 00009365 | |||||||||
| 00009366 | |||||||||
| 00009367 | |||||||||
| 00123876 | |||||||||
| Contained_in_operon | CEOP1276 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | cir-1 is a nuclear protein homologous to mammalian CIR, a component of the co-repressor complex which associates with CBF1 in mammals (OMIM:605228); cir-1 is required for larval and different aspects of germ line development from proliferation and gonad extension, to progression of meiosis; cir-1 mutants cause 90% of larvae to cease development at larval stage1, escapers are lethargic and show defects in nucleolar morphology; cir-1 RNAi results into 100% embryonic lethality indicating that cir-1 is required maternally for embryonic development and zygotically for later stages of development for robust germline proliferation, oogenesis and vulval formation; CIR-1, MOG-3 and MEP-1 belong to single complex; CIR-1 expression coincides with mog-3::GFP; similar to MOG-3, CIR-1 is detected in somatic and meiotic nuclei as well as developing L4 vulva. | Paper_evidence | WBPaper00036278 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 03 Jun 2011 00:00:00 | ||||||||
| Automated_description | Enables protein self-association. Involved in oogenesis. Located in nucleus. Is an ortholog of human CIR1 (corepressor interacting with RBPJ, CIR1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F55F8.4 | |||||||
| Corresponding_transcript | F55F8.4.1 | ||||||||
| F55F8.4.2 | |||||||||
| Other_sequence (60) | |||||||||
| Associated_feature | WBsf219465 | ||||||||
| WBsf219466 | |||||||||
| Experimental_info | RNAi_result (37) | ||||||||
| Expr_pattern | Expr1025987 | ||||||||
| Expr1038151 | |||||||||
| Expr1152313 | |||||||||
| Expr2010018 | |||||||||
| Expr2028259 | |||||||||
| Drives_construct | WBCnstr00026207 | ||||||||
| Construct_product | WBCnstr00026207 | ||||||||
| Antibody | WBAntibody00002141 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (48) | |||||||||
| Map_info | Map | I | Position | 0.294728 | Error | 0.002907 | |||
| Positive | Positive_clone | F55F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5152 | |||||||
| 5278 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031805 | ||||||||
| WBPaper00034241 | |||||||||
| WBPaper00036278 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00046148 | |||||||||
| WBPaper00048493 | |||||||||
| WBPaper00050247 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00065308 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
