WormBase Tree Display for Gene: WBGene00002007
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| WBGene00002007 | SMap | S_parent | Sequence | C15H9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-3 | Person_evidence | WBPerson36 | |||||
| Sequence_name | C15H9.6 | ||||||||
| Molecular_name | C15H9.6a | ||||||||
| C15H9.6a.1 | |||||||||
| CE08177 | |||||||||
| C15H9.6b | |||||||||
| CE49317 | |||||||||
| C15H9.6a.2 | |||||||||
| C15H9.6b.1 | |||||||||
| Other_name | hsp70er1 | Paper_evidence | WBPaper00064398 | ||||||
| CELE_C15H9.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | hsp-3 | ||||||||
| DB_info | Database | AceView | gene | XG708 | |||||
| WormQTL | gene | WBGene00002007 | |||||||
| WormFlux | gene | WBGene00002007 | |||||||
| NDB | locus_tag | CELE_C15H9.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002007|UniProtKB=P27420 | |||||||
| family | PTHR19375 | ||||||||
| NCBI | gene | 180880 | |||||||
| RefSeq | protein | NM_001383595.2 | |||||||
| NM_001307849.4 | |||||||||
| SwissProt | UniProtAcc | P27420 | |||||||
| TrEMBL | UniProtAcc | V6CJ24 | |||||||
| UniProt_GCRP | UniProtAcc | P27420 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (57) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes protein related to mammalian grp78/BiP; not heat shock induced. [Heschl and Baillie 1990; BC] | ||||||||
| Strain | WBStrain00031808 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (53) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | hsp-3 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; hsp-3 transcription is, however, upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. | Paper_evidence | WBPaper00001136 | |||||
| WBPaper00001320 | |||||||||
| WBPaper00005044 | |||||||||
| WBPaper00031857 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Aug 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen; membrane; and nucleus. Predicted to be part of endoplasmic reticulum chaperone complex. Expressed in several structures, including germ line; hypodermis; intestinal muscle; pharyngeal-intestinal valve; and tail. Human ortholog(s) of this gene implicated in several diseases, including dopamine beta-hydroxylase deficiency; inflammatory bowel disease; and rheumatoid arthritis. Is an ortholog of human HSPA5 (heat shock protein family A (Hsp70) member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||
| DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| DOID:0090145 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| DOID:0050589 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5238) | ||||||
| Molecular_info | Corresponding_CDS | C15H9.6a | |||||||
| C15H9.6b | |||||||||
| Corresponding_transcript | C15H9.6a.1 | ||||||||
| C15H9.6a.2 | |||||||||
| C15H9.6b.1 | |||||||||
| Other_sequence (280) | |||||||||
| Associated_feature (25) | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002023 | ||||||||
| WBCnstr00002024 | |||||||||
| WBCnstr00009609 | |||||||||
| WBCnstr00015264 | |||||||||
| WBCnstr00019129 | |||||||||
| WBCnstr00036526 | |||||||||
| Construct_product | WBCnstr00036526 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (247) | |||||||||
| Interaction (318) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| WBbiopr:00000046 | |||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | X | Position | -3.73772 | Error | 0.017656 | |||
| Positive | Positive_clone | BC#HS148 | |||||||
| C15H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4344 | |||||||
| 4540 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (46) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
