WormBase Tree Display for Gene: WBGene00000140
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| WBGene00000140 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | anc-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK973.6 | ||||||||
| Molecular_name | ZK973.6a | ||||||||
| ZK973.6a.1 | |||||||||
| CE33588 | |||||||||
| ZK973.6b | |||||||||
| CE52283 | |||||||||
| ZK973.6c | |||||||||
| CE52179 | |||||||||
| ZK973.6b.1 | |||||||||
| ZK973.6c.1 | |||||||||
| Other_name | T03A1.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| T03A1.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_ZK973.6 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | anc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (13) | |||||||||
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||
| Accession_evidence | OMIM | 612998 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Feb 2013 00:00:00 | ||||||||
| Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | |||||
| DOID:0070249 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| DOID:0070250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17084) | ||||||
| DOID:0080954 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| DOID:0050753 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| DOID:0080979 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| DOID:0111618 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) | ||||||
| Disease_relevance | The human ortholog of anc-1, SYNE1 (spectrin repeat containing, nuclear envelope 1) encodes for the Nesprin 1 protein; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia; Nesprin 1 belongs to the family of mammalian KASH domain proteins; vertebrates have Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; KASH-domain proteins along with SUN-domain proteins form a LINC (linker of nucleoskeleton and cytoskeleton) complex which links components of the nucleus with the cytoplasm; studies in elegans show that anc-1 interacts with actin and is involved in nuclear positioning and migration; anc-1 requires the SUN domain protein UNC-84, orthologous to mammalian SUN1 and SUN2 proteins, for its nuclear localization. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
| Accession_evidence | OMIM | 612998 | |||||||
| 610743 | |||||||||
| 608441 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Mar 2012 00:00:00 | ||||||||
| Modifies_disease | DOID:070355 | ||||||||
| Models_disease_in_annotation | WBDOannot00000048 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001302 | ||||||||
| Molecular_info | Corresponding_CDS | ZK973.6a | |||||||
| ZK973.6b | |||||||||
| ZK973.6c | |||||||||
| Corresponding_CDS_history | ZK973.6:wp96 | ||||||||
| Corresponding_transcript | ZK973.6a.1 | ||||||||
| ZK973.6b.1 | |||||||||
| ZK973.6c.1 | |||||||||
| Other_sequence (97) | |||||||||
| Associated_feature (28) | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Chronogram1817 | ||||||||
| Expr2219 | |||||||||
| Expr2220 | |||||||||
| Expr12539 | |||||||||
| Expr1027397 | |||||||||
| Expr1030073 | |||||||||
| Expr1163298 | |||||||||
| Expr2009333 | |||||||||
| Expr2027569 | |||||||||
| Drives_construct | WBCnstr00003410 | ||||||||
| Construct_product | WBCnstr00010709 | ||||||||
| Regulate_expr_cluster | WBPaper00060317:anc-1(RNAi)_downregulated | ||||||||
| WBPaper00060317:anc-1(RNAi)_upregulated | |||||||||
| Antibody | WBAntibody00000559 | ||||||||
| Microarray_results (43) | |||||||||
| Expression_cluster (249) | |||||||||
| Interaction (51) | |||||||||
| Map_info | Map | I | Position | -1.5 | Error | 0.011025 | |||
| Positive | Positive_clone | ZK973 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 642 | |||||||
| Multi_point | 572 | ||||||||
| 573 | |||||||||
| 574 | |||||||||
| 575 | |||||||||
| 5329 | |||||||||
| Pos_neg_data | 6698 | ||||||||
| 6699 | |||||||||
| Reference (46) | |||||||||
| Remark | Starr DA, Han M, modified prediction. [021111 ck1] | ||||||||
| Method | Gene |
