WormBase Tree Display for Gene: WBGene00000776
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| WBGene00000776 | Evidence | Paper_evidence | WBPaper00004821 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T03E6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cpl-1 | |||||||
| Sequence_name | T03E6.7 | ||||||||
| Molecular_name | T03E6.7a | ||||||||
| T03E6.7a.1 | |||||||||
| CE16333 | |||||||||
| T03E6.7b | |||||||||
| CE47424 | |||||||||
| T03E6.7b.1 | |||||||||
| Other_name | CELE_T03E6.7 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cpl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cpl | ||||||||
| Allele (188) | |||||||||
| Strain | WBStrain00035678 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (69) | |||||||||
| Paralog (28) | |||||||||
| Structured_description | Concise_description | cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. | Paper_evidence | WBPaper00005099 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00011657 | |||||||||
| WBPaper00023209 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) | ||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) | ||||||
| Molecular_info | Corresponding_CDS | T03E6.7a | |||||||
| T03E6.7b | |||||||||
| Corresponding_transcript | T03E6.7a.1 | ||||||||
| T03E6.7b.1 | |||||||||
| Other_sequence (287) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00002531 | ||||||||
| WBCnstr00010433 | |||||||||
| WBCnstr00010434 | |||||||||
| WBCnstr00019401 | |||||||||
| WBCnstr00037285 | |||||||||
| Construct_product | WBCnstr00010434 | ||||||||
| WBCnstr00015512 | |||||||||
| WBCnstr00016652 | |||||||||
| WBCnstr00018463 | |||||||||
| WBCnstr00018464 | |||||||||
| WBCnstr00019401 | |||||||||
| WBCnstr00037285 | |||||||||
| Regulate_expr_cluster | WBPaper00064728:cpl-1(W32AY35A)_upregulated | ||||||||
| Antibody | WBAntibody00000451 | ||||||||
| WBAntibody00000800 | |||||||||
| WBAntibody00000801 | |||||||||
| WBAntibody00000802 | |||||||||
| WBAntibody00000803 | |||||||||
| WBAntibody00002885 | |||||||||
| WBAntibody00002910 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (236) | |||||||||
| Interaction (107) | |||||||||
| Map_info | Map | V | Position | 10.72 | |||||
| Positive | Positive_clone | T03E6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4236 | |||||||
| Pseudo_map_position | |||||||||
| Reference (37) | |||||||||
| Remark | Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333) | |||||||||
| Method | Gene |
