WormBase Tree Display for Gene: WBGene00000776

WBGene00000776 Evidence: Paper_evidence: WBPaper00004821
  SMap: S_parent: Sequence: T03E6
  Identity: Version: 1
    Name: CGC_name: cpl-1
      Sequence_name: T03E6.7
      Molecular_name: T03E6.7a
        T03E6.7a.1
        CE16333
        T03E6.7b
        CE47424
        T03E6.7b.1
      Other_name: CELE_T03E6.7 Accession_evidence: NDB BX284605
      Public_name: cpl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpl
    Allele (188)
    Strain: WBStrain00035678
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (69)
    Paralog (28)
    Structured_description: Concise_description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. Paper_evidence: WBPaper00005099
            WBPaper00005654
            WBPaper00011657
            WBPaper00023209
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
  Molecular_info: Corresponding_CDS: T03E6.7a
      T03E6.7b
    Corresponding_transcript: T03E6.7a.1
      T03E6.7b.1
    Other_sequence (287)
    Associated_feature (13)
  Experimental_info: RNAi_result (20)
    Expr_pattern (17)
    Drives_construct: WBCnstr00002531
      WBCnstr00010433
      WBCnstr00010434
      WBCnstr00019401
      WBCnstr00037285
    Construct_product: WBCnstr00010434
      WBCnstr00015512
      WBCnstr00016652
      WBCnstr00018463
      WBCnstr00018464
      WBCnstr00019401
      WBCnstr00037285
    Regulate_expr_cluster: WBPaper00064728:cpl-1(W32AY35A)_upregulated
    Antibody: WBAntibody00000451
      WBAntibody00000800
      WBAntibody00000801
      WBAntibody00000802
      WBAntibody00000803
      WBAntibody00002885
      WBAntibody00002910
    Microarray_results (23)
    Expression_cluster (236)
    Interaction: WBInteraction000028633
      WBInteraction000028996
      WBInteraction000030179
      WBInteraction000030180
      WBInteraction000040898
      WBInteraction000160924
      WBInteraction000162872
      WBInteraction000162873
      WBInteraction000162874
      WBInteraction000162875
      WBInteraction000162876
      WBInteraction000167065
      WBInteraction000169108
      WBInteraction000185647
      WBInteraction000186518
      WBInteraction000186724
      WBInteraction000187504
      WBInteraction000188993
      WBInteraction000190070
      WBInteraction000203585
      WBInteraction000218070
      WBInteraction000218114
      WBInteraction000219929
      WBInteraction000225317
      WBInteraction000226306
      WBInteraction000228925
      WBInteraction000232845
      WBInteraction000235662
      WBInteraction000236929
      WBInteraction000245472
      WBInteraction000255701
      WBInteraction000261097
      WBInteraction000271366
      WBInteraction000302205
      WBInteraction000314496
      WBInteraction000332981
      WBInteraction000360670
      WBInteraction000361715
      WBInteraction000365374
      WBInteraction000369426
      WBInteraction000376975
      WBInteraction000384096
      WBInteraction000398414
      WBInteraction000398592
      WBInteraction000406099
      WBInteraction000408603
      WBInteraction000421516
      WBInteraction000432881
      WBInteraction000442114
      WBInteraction000444165
      WBInteraction000446972
      WBInteraction000447240
      WBInteraction000461512
      WBInteraction000461844
      WBInteraction000500995
      WBInteraction000501003
      WBInteraction000501004
      WBInteraction000501005
      WBInteraction000501006
      WBInteraction000501562
      WBInteraction000501564
      WBInteraction000514898
      WBInteraction000514925
      WBInteraction000514931
      WBInteraction000523303
      WBInteraction000536473
      WBInteraction000536545
      WBInteraction000536755
      WBInteraction000536758
      WBInteraction000536760
      WBInteraction000536763
      WBInteraction000536765
      WBInteraction000538994
      WBInteraction000539819
      WBInteraction000543812
      WBInteraction000543840
      WBInteraction000544043
      WBInteraction000544352
      WBInteraction000550978
      WBInteraction000556618
      WBInteraction000558611
      WBInteraction000558781
      WBInteraction000560180
      WBInteraction000560509
      WBInteraction000560796
      WBInteraction000560892
      WBInteraction000562235
      WBInteraction000562425
      WBInteraction000562717
      WBInteraction000566016
      WBInteraction000566489
      WBInteraction000566768
      WBInteraction000569415
      WBInteraction000570142
      WBInteraction000570655
      WBInteraction000572394
      WBInteraction000572933
      WBInteraction000574026
      WBInteraction000574944
      WBInteraction000576114
      WBInteraction000577511
      WBInteraction000579920
      WBInteraction000581954
      WBInteraction000582501
      WBInteraction000582861
      WBInteraction000585294
      WBInteraction000586090
  Map_info: Map: V Position: 10.72
    Positive: Positive_clone: T03E6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4236
    Pseudo_map_position
  Reference (37)
  Remark: Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333)
  Method: Gene