WormBase Tree Display for Gene: WBGene00000776
expand all nodes | collapse all nodes | view schema
WBGene00000776 | Evidence | Paper_evidence | WBPaper00004821 | |||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T03E6 | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | cpl | |||||
Allele (188) | ||||||
Strain | WBStrain00035678 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (34) | ||||||
Ortholog (69) | ||||||
Paralog (28) | ||||||
Structured_description | Concise_description | cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. | Paper_evidence | WBPaper00005099 | ||
WBPaper00005654 | ||||||
WBPaper00011657 | ||||||
WBPaper00023209 | ||||||
Curator_confirmed | WBPerson48 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Automated_description | Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) | |
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2537) | |||
Molecular_info | Corresponding_CDS | T03E6.7a | ||||
T03E6.7b | ||||||
Corresponding_transcript | T03E6.7a.1 | |||||
T03E6.7b.1 | ||||||
Other_sequence (287) | ||||||
Associated_feature (13) | ||||||
Experimental_info | RNAi_result (20) | |||||
Expr_pattern (17) | ||||||
Drives_construct | WBCnstr00002531 | |||||
WBCnstr00010433 | ||||||
WBCnstr00010434 | ||||||
WBCnstr00019401 | ||||||
WBCnstr00037285 | ||||||
Construct_product | WBCnstr00010434 | |||||
WBCnstr00015512 | ||||||
WBCnstr00016652 | ||||||
WBCnstr00018463 | ||||||
WBCnstr00018464 | ||||||
WBCnstr00019401 | ||||||
WBCnstr00037285 | ||||||
Regulate_expr_cluster | WBPaper00064728:cpl-1(W32AY35A)_upregulated | |||||
Antibody | WBAntibody00000451 | |||||
WBAntibody00000800 | ||||||
WBAntibody00000801 | ||||||
WBAntibody00000802 | ||||||
WBAntibody00000803 | ||||||
WBAntibody00002885 | ||||||
WBAntibody00002910 | ||||||
Microarray_results (23) | ||||||
Expression_cluster (236) | ||||||
Interaction (107) | ||||||
Map_info | Map | V | Position | 10.72 | ||
Positive | Positive_clone | T03E6 | Inferred_automatically | From CDS info | ||
From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4236 | ||||
Pseudo_map_position | ||||||
Reference (37) | ||||||
Remark | Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb. | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
[200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333) | ||||||
Method | Gene |