WormBase Tree Display for Gene: WBGene00003369
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| WBGene00003369 | SMap | S_parent | Sequence | C36E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mlc-1 | Person_evidence | WBPerson21 | |||||
| Sequence_name | C36E6.3 | ||||||||
| Molecular_name | C36E6.3 | ||||||||
| C36E6.3.1 | |||||||||
| CE34269 | |||||||||
| Other_name | C36E6.f | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_C36E6.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mlc-1 | ||||||||
| DB_info | Database | AceView | gene | XS73 | |||||
| WormQTL | gene | WBGene00003369 | |||||||
| WormFlux | gene | WBGene00003369 | |||||||
| NDB | locus_tag | CELE_C36E6.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003369|UniProtKB=P19625 | |||||||
| family | PTHR23049 | ||||||||
| NCBI | gene | 181776 | |||||||
| RefSeq | protein | NM_078428.8 | |||||||
| SwissProt | UniProtAcc | P19625 | |||||||
| UniProt_GCRP | UniProtAcc | P19625 | |||||||
| OMIM | gene | 160781 | |||||||
| 617378 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mlc | ||||||||
| Allele (20) | |||||||||
| Legacy_information | [C.elegansII] Deletions (eg sup-10(n184)) viable, normal muscle; increased lethality of mlc-2(0).Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall. Not transpliced. [Cummins and Anderson 1988; TR] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (72) | |||||||||
| Paralog | WBGene00003370 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003372 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mlc-1 encodes a muscle regulatory myosin light chain that is nearly identical to MLC-2 and functions redundantly with MLC-2 in the body-wall and in pharyngeal muscle to affect L1 larval viability, elongation, and pharyngeal and body-wall muscle development, and also affects locomotion and growth; expressed in the body-wall muscles, pharyngeal muscles, and vulval muscles. | Paper_evidence | WBPaper00001094 | |||||
| WBPaper00003259 | |||||||||
| WBPaper00006395 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 09 Aug 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29824) | ||||
| DOID:0110316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| Molecular_info | Corresponding_CDS | C36E6.3 | |||||||
| Corresponding_CDS_history | C36E6.3:wp102 | ||||||||
| Corresponding_transcript | C36E6.3.1 | ||||||||
| Other_sequence (127) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042074 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00024757 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027213 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011705 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011703 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059498 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2736 | ||||||||
| Expr4931 | |||||||||
| Expr1023343 | |||||||||
| Expr1031548 | |||||||||
| Expr1146071 | |||||||||
| Expr2013589 | |||||||||
| Expr2031822 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00036156 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (253) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | X | Position | 24.14 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | C36E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK54 | |||||||||
| Mapping_data | Multi_point | 4734 | |||||||
| Pos_neg_data | 5855 | ||||||||
| 5856 | |||||||||
| 5857 | |||||||||
| 5858 | |||||||||
| 5859 | |||||||||
| 5860 | |||||||||
| 5861 | |||||||||
| Reference (41) | |||||||||
| Remark | 2 sequences can't be resolved yet, big duplication in cosmid which is not fully analysed. see also mlc-2. sdm 12/00 | ||||||||
| However, blastn of genomic EMBL sequence to genomic clones : mlc-1 matches 100% to C36E6.f apart from 5' exon. So removing .b sequence from here. sdm 12/00 | |||||||||
| C36E6.f changed to .3 [sdm 0103] | |||||||||
| Method | Gene |
