WormBase Tree Display for Gene: WBGene00003370
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| WBGene00003370 | SMap | S_parent | Sequence | C36E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mlc-2 | Person_evidence | WBPerson21 | |||||
| Sequence_name | C36E6.5 | ||||||||
| Molecular_name | C36E6.5 | ||||||||
| C36E6.5.1 | |||||||||
| CE20542 | |||||||||
| Other_name | CELE_C36E6.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mlc-2 | ||||||||
| DB_info | Database | AceView | gene | XS70 | |||||
| WormQTL | gene | WBGene00003370 | |||||||
| WormFlux | gene | WBGene00003370 | |||||||
| NDB | locus_tag | CELE_C36E6.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003370|UniProtKB=P19626 | |||||||
| family | PTHR23049 | ||||||||
| NCBI | gene | 181775 | |||||||
| RefSeq | protein | NM_078427.10 | |||||||
| SwissProt | UniProtAcc | P19626 | |||||||
| UniProt_GCRP | UniProtAcc | P19626 | |||||||
| OMIM | gene | 160781 | |||||||
| 617378 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mlc | ||||||||
| Allele (24) | |||||||||
| Legacy_information | [C.elegansII] Deletion exhibits pharyngeal pumping defect,10% reach fertile adulthood (most males reach adulthood). Deletion of both mlc-1 and mlc-2 leads to lethal arrest as short lumpy paralysed L1/L2. Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall; SL1transpliced. [Cummins and Anderson 1988; Rushforth et al. 1993; TR] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (72) | |||||||||
| Paralog | WBGene00003369 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003372 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mlc-2 encodes, along with mlc-1 and mlc-4, one of three C. elegans regulatory myosin light chains; MLC-2 is predicted to function as a regulator of myosin ATPase activity, and genetic studies indicate that MLC-2 is nearly essential in hermaphrodites for normal pharyngeal muscle function, but redundant with MLC-1, with which it is nearly identical, for proper bodywall muscle development; accordingly, loss of mlc-2 activity eventually results in larval lethality, as animals are not able to feed properly; mlc-2 mRNA is expressed in bodywall, pharyngeal, and vulval muscles. | Paper_evidence | WBPaper00003259 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of pharyngeal pumping. Predicted to be located in cytoplasm. Predicted to be part of myosin II complex. Expressed in body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29824) | ||||
| DOID:0110316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
| Molecular_info | Corresponding_CDS | C36E6.5 | |||||||
| Corresponding_transcript | C36E6.5.1 | ||||||||
| Other_sequence (140) | |||||||||
| Associated_feature | WBsf654741 | ||||||||
| WBsf1008927 | |||||||||
| WBsf1025040 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr2737 | ||||||||
| Expr4001 | |||||||||
| Expr1031549 | |||||||||
| Expr1146072 | |||||||||
| Expr2013590 | |||||||||
| Expr2031823 | |||||||||
| Drives_construct | WBCnstr00036155 | ||||||||
| WBCnstr00041971 | |||||||||
| WBCnstr00041982 | |||||||||
| WBCnstr00042092 | |||||||||
| Construct_product | WBCnstr00036155 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (231) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | X | Position | 24.1039 | Error | 0.002498 | |||
| Positive | Positive_clone | C36E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK54 | |||||||||
| Mapping_data | Pos_neg_data | 5862 | |||||||
| 5863 | |||||||||
| 5864 | |||||||||
| 5865 | |||||||||
| 5866 | |||||||||
| 5867 | |||||||||
| 5868 | |||||||||
| Reference (32) | |||||||||
| Remark | blastN of whole EMBL sequence to genomic canonical gives 100% match to C36E6.b. sdm 12/00 | ||||||||
| C36E6.b changed to .5 [sdm 0103] | |||||||||
| Method | Gene |
