WormBase Tree Display for Gene: WBGene00003370
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WBGene00003370 | SMap | S_parent | Sequence | C36E6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | mlc-2 | Person_evidence | WBPerson21 | |||||
Sequence_name | C36E6.5 | ||||||||
Molecular_name | C36E6.5 | ||||||||
C36E6.5.1 | |||||||||
CE20542 | |||||||||
Other_name | CELE_C36E6.5 | Accession_evidence | NDB | BX284606 | |||||
Public_name | mlc-2 | ||||||||
DB_info | Database | AceView | gene | XS70 | |||||
WormQTL | gene | WBGene00003370 | |||||||
WormFlux | gene | WBGene00003370 | |||||||
NDB | locus_tag | CELE_C36E6.5 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003370|UniProtKB=P19626 | |||||||
family | PTHR23049 | ||||||||
NCBI | gene | 181775 | |||||||
RefSeq | protein | NM_078427.10 | |||||||
SwissProt | UniProtAcc | P19626 | |||||||
UniProt_GCRP | UniProtAcc | P19626 | |||||||
OMIM | gene | 160781 | |||||||
617378 | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mlc | ||||||||
Allele (24) | |||||||||
Legacy_information | [C.elegansII] Deletion exhibits pharyngeal pumping defect,10% reach fertile adulthood (most males reach adulthood). Deletion of both mlc-1 and mlc-2 leads to lethal arrest as short lumpy paralysed L1/L2. Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall; SL1transpliced. [Cummins and Anderson 1988; Rushforth et al. 1993; TR] | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Ortholog (72) | |||||||||
Paralog | WBGene00003369 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00003372 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | mlc-2 encodes, along with mlc-1 and mlc-4, one of three C. elegans regulatory myosin light chains; MLC-2 is predicted to function as a regulator of myosin ATPase activity, and genetic studies indicate that MLC-2 is nearly essential in hermaphrodites for normal pharyngeal muscle function, but redundant with MLC-1, with which it is nearly identical, for proper bodywall muscle development; accordingly, loss of mlc-2 activity eventually results in larval lethality, as animals are not able to feed properly; mlc-2 mRNA is expressed in bodywall, pharyngeal, and vulval muscles. | Paper_evidence | WBPaper00003259 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 11 Oct 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of pharyngeal pumping. Predicted to be located in cytoplasm. Predicted to be part of myosin II complex. Expressed in body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0112190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29824) | ||||
DOID:0110316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | ||||||
Molecular_info | Corresponding_CDS | C36E6.5 | |||||||
Corresponding_transcript | C36E6.5.1 | ||||||||
Other_sequence (140) | |||||||||
Associated_feature | WBsf654741 | ||||||||
WBsf1008927 | |||||||||
WBsf1025040 | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern | Expr2737 | ||||||||
Expr4001 | |||||||||
Expr1031549 | |||||||||
Expr1146072 | |||||||||
Expr2013590 | |||||||||
Expr2031823 | |||||||||
Drives_construct | WBCnstr00036155 | ||||||||
WBCnstr00041971 | |||||||||
WBCnstr00041982 | |||||||||
WBCnstr00042092 | |||||||||
Construct_product | WBCnstr00036155 | ||||||||
Microarray_results (15) | |||||||||
Expression_cluster (231) | |||||||||
Interaction (39) | |||||||||
Map_info | Map | X | Position | 24.1039 | Error | 0.002498 | |||
Positive | Positive_clone | C36E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
ZK54 | |||||||||
Mapping_data | Pos_neg_data | 5862 | |||||||
5863 | |||||||||
5864 | |||||||||
5865 | |||||||||
5866 | |||||||||
5867 | |||||||||
5868 | |||||||||
Reference | WBPaper00001092 | ||||||||
WBPaper00001094 | |||||||||
WBPaper00001230 | |||||||||
WBPaper00001617 | |||||||||
WBPaper00001672 | |||||||||
WBPaper00001754 | |||||||||
WBPaper00001772 | |||||||||
WBPaper00001813 | |||||||||
WBPaper00002354 | |||||||||
WBPaper00003259 | |||||||||
WBPaper00003624 | |||||||||
WBPaper00006047 | |||||||||
WBPaper00013746 | |||||||||
WBPaper00013770 | |||||||||
WBPaper00013846 | |||||||||
WBPaper00013985 | |||||||||
WBPaper00014375 | |||||||||
WBPaper00014485 | |||||||||
WBPaper00014490 | |||||||||
WBPaper00014561 | |||||||||
WBPaper00014616 | |||||||||
WBPaper00016374 | |||||||||
WBPaper00020856 | |||||||||
WBPaper00020980 | |||||||||
WBPaper00021105 | |||||||||
WBPaper00022127 | |||||||||
WBPaper00024630 | |||||||||
WBPaper00027253 | |||||||||
WBPaper00029197 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00049828 | |||||||||
WBPaper00055090 | |||||||||
Remark | blastN of whole EMBL sequence to genomic canonical gives 100% match to C36E6.b. sdm 12/00 | ||||||||
C36E6.b changed to .5 [sdm 0103] | |||||||||
Method | Gene |