WormBase Tree Display for Gene: WBGene00002053
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| WBGene00002053 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F10C1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ifb-1 | Person_evidence | WBPerson105 | |||||
| WBPerson293 | |||||||||
| Sequence_name | F10C1.2 | ||||||||
| Molecular_name | F10C1.2a | ||||||||
| F10C1.2a.1 | |||||||||
| CE02618 | |||||||||
| F10C1.2b | |||||||||
| CE02619 | |||||||||
| F10C1.2b.1 | |||||||||
| Other_name | vab-21 | ||||||||
| Cel IF b1 | Accession_evidence | X70830 | |||||||
| CelIF b1 | |||||||||
| B1 | Paper_evidence | WBPaper00006137 | |||||||
| CELE_F10C1.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | ifb-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ifb | ||||||||
| Allele (100) | |||||||||
| Legacy_information | Variable abnormal morphology | ||||||||
| Strain | WBStrain00002879 | ||||||||
| WBStrain00005384 | |||||||||
| WBStrain00005392 | |||||||||
| WBStrain00031953 | |||||||||
| WBStrain00032433 | |||||||||
| WBStrain00005396 | |||||||||
| WBStrain00030105 | |||||||||
| WBStrain00030106 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | ifb-1 (also known as vab-21) encodes two isoforms of an essential intermediate filament protein that is coexpressed with the essential IF proteins IFA-1, IFA-2, and IFA-3, along with IFA-4; IFB-1 is required for embryonic development and epidermal morphogenesis; IFB-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFA-1, IFA-2, or IFA-3, and binds IFA-4 in blot overlay assays; IFB-1 resides in attachment structures of epidermal cells, found in sites undergoing mechanical stress; the two isoforms are expressed in different tissues and have distinct functions, since ifb-1A(RNAi) larvae have detached muscle cells, while ifb-1B(RNAi) larvae have detached cuticle. | Paper_evidence | WBPaper00001981 | |||||
| WBPaper00004761 | |||||||||
| WBPaper00006137 | |||||||||
| WBPaper00018043 | |||||||||
| WBPaper00018776 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Located in apical plasma membrane. Expressed in several structures, including egg-laying apparatus; excretory system; pharyngeal-intestinal valve; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) | ||||
| DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) | ||||||
| DOID:0080299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6638) | ||||||
| Molecular_info | Corresponding_CDS | F10C1.2a | |||||||
| F10C1.2b | |||||||||
| Corresponding_transcript | F10C1.2a.1 | ||||||||
| F10C1.2b.1 | |||||||||
| Other_sequence (161) | |||||||||
| Associated_feature (21) | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000385 | ||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (231) | |||||||||
| Interaction (110) | |||||||||
| Map_info | Map | II | Position | -0.952783 | Error | 0.004521 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F10C1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3896 | |||||||
| 3897 | |||||||||
| 5321 | |||||||||
| Reference (47) | |||||||||
| Remark | Sequence connection from [Chisholm AD] | ||||||||
| old_name vab-21 becomes new_name ifb-1 from [Chisholm AD]. | |||||||||
| Method | Gene |
