WormBase Tree Display for Gene: WBGene00003153
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| WBGene00003153 | SMap | S_parent | Sequence | Y67D8C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mca-3 | |||||||
| Sequence_name | Y67D8C.10 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | cup-7 | Person_evidence | WBPerson170 | ||||||
| CELE_Y67D8C.10 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mca-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Acquires_merge | WBGene00000847 | ||
| Imported | Initial conversion from geneace | ||||||||
| 2 | 09 Oct 2007 09:36:44 | WBPerson2970 | Name_change | Other_name | cup-7 | ||||
| Acquires_merge | WBGene00000847 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mca | ||||||||
| Allele (491) | |||||||||
| Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. | ||||||||
| Strain | WBStrain00032351 | ||||||||
| WBStrain00008044 | |||||||||
| WBStrain00008045 | |||||||||
| WBStrain00007591 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (55) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. | Paper_evidence | WBPaper00003407 | |||||
| WBPaper00004883 | |||||||||
| WBPaper00029172 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) | ||||
| DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) | ||||||
| DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| Molecular_info | Corresponding_CDS | Y67D8C.10a | |||||||
| Y67D8C.10b | |||||||||
| Y67D8C.10c | |||||||||
| Y67D8C.10d | |||||||||
| Y67D8C.10e | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (125) | |||||||||
| Associated_feature (33) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103077 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00009413 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110940 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00057995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103078 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103079 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066558 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021260 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8320 | ||||||||
| Expr8321 | |||||||||
| Expr12128 | |||||||||
| Expr1024986 | |||||||||
| Expr1031488 | |||||||||
| Expr1161419 | |||||||||
| Expr2013444 | |||||||||
| Expr2031678 | |||||||||
| Drives_construct | WBCnstr00008391 | ||||||||
| Construct_product | WBCnstr00000243 | ||||||||
| WBCnstr00000246 | |||||||||
| WBCnstr00000247 | |||||||||
| Microarray_results (52) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | IV | Position | -5.83327 | Error | 0.101838 | |||
| Positive | Positive_clone | Y67D8 | |||||||
| Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3954 | |||||||
| Reference (11) | |||||||||
| Method | Gene |
