WormBase Tree Display for Gene: WBGene00003963
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| WBGene00003963 | SMap | S_parent | Sequence | C07A12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pdi-2 | Person_evidence | WBPerson466 | |||||
| Sequence_name | C07A12.4 | ||||||||
| Molecular_name | C07A12.4 | ||||||||
| C07A12.4.1 | |||||||||
| CE03972 | |||||||||
| C07A12.4.2 | |||||||||
| Other_name | CELE_C07A12.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pdi-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pdi | ||||||||
| Allele (51) | |||||||||
| Strain | WBStrain00002794 | ||||||||
| WBStrain00034929 | |||||||||
| WBStrain00034930 | |||||||||
| WBStrain00036011 | |||||||||
| WBStrain00036126 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | pdi-2 encodes a protein disulfide isomerase beta subunit; by homology, PDI-2 is predicted to function in oxidative protein folding in the endoplasmic reticulum (ER); PDI-2 activity is required for several organismal processes including body morphology, locomotion, fertility, molting, and collagen deposition; pdi-2 transcript levels are increased in response to ER stress; pdi-2 is expressed in the hypodermis which secretes the collagen-based cuticle. | Paper_evidence | WBPaper00005422 | |||||
| WBPaper00005432 | |||||||||
| WBPaper00030802 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Contributes to peptidyl-proline 4-dioxygenase activity. Involved in macromolecule modification and obsolete oxidation-reduction process. Located in endoplasmic reticulum. Part of procollagen-proline 4-dioxygenase complex. Expressed in several structures, including germ line and hypodermis. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human P4HB (prolyl 4-hydroxylase subunit beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060438 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8548) | ||||
| Molecular_info | Corresponding_CDS | C07A12.4 | |||||||
| Corresponding_CDS_history | C07A12.4b:wp172 | ||||||||
| C07A12.4b:wp271 | |||||||||
| C07A12.4c:wp271 | |||||||||
| Corresponding_transcript | C07A12.4.1 | ||||||||
| C07A12.4.2 | |||||||||
| Other_sequence (458) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Chronogram1612 | ||||||||
| Expr1930 | |||||||||
| Expr1933 | |||||||||
| Expr4051 | |||||||||
| Expr1022503 | |||||||||
| Expr1031887 | |||||||||
| Expr1144042 | |||||||||
| Expr2014806 | |||||||||
| Expr2033040 | |||||||||
| Drives_construct | WBCnstr00001638 | ||||||||
| WBCnstr00003321 | |||||||||
| WBCnstr00006664 | |||||||||
| WBCnstr00010526 | |||||||||
| WBCnstr00014417 | |||||||||
| WBCnstr00035770 | |||||||||
| Construct_product | WBCnstr00035770 | ||||||||
| Antibody | WBAntibody00000540 | ||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (292) | |||||||||
| Interaction (251) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | X | Position | -7.35044 | Error | 0.00847 | |||
| Positive | Positive_clone | C07A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4692 | |||||||
| Pseudo_map_position | |||||||||
| Reference (40) | |||||||||
| Remark | Sequence connections from Darin St. Louis [020930 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
