WormBase Tree Display for Gene: WBGene00000883
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| WBGene00000883 | SMap | S_parent | Sequence | Y75B12B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyn-7 | Person_evidence | WBPerson466 | |||||
| Sequence_name | Y75B12B.2 | ||||||||
| Molecular_name | Y75B12B.2 | ||||||||
| Y75B12B.2.1 | |||||||||
| CE20371 | |||||||||
| Other_name | cyp-7 | Person_evidence | WBPerson466 | ||||||
| CELE_Y75B12B.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cyn-7 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Sep 2004 16:20:03 | WBPerson1971 | Name_change | CGC_name | cyp-7 -> cyn-7 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyn | ||||||||
| Allele (26) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cyclophilin family. Signal peptide. [TP] | ||||||||
| Strain | WBStrain00032910 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (63) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays. | Paper_evidence | WBPaper00002472 | |||||
| WBPaper00004651 | |||||||||
| WBPaper00026884 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| Molecular_info | Corresponding_CDS | Y75B12B.2 | |||||||
| Corresponding_transcript | Y75B12B.2.1 | ||||||||
| Other_sequence (63) | |||||||||
| Associated_feature | WBsf653438 | ||||||||
| WBsf653439 | |||||||||
| WBsf977373 | |||||||||
| WBsf977374 | |||||||||
| WBsf235037 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00111702 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001940 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058420 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027817 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00083853 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00083670 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021427 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076846 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1064 | ||||||||
| Expr1022229 | |||||||||
| Expr1030548 | |||||||||
| Expr1161841 | |||||||||
| Expr2010675 | |||||||||
| Expr2028915 | |||||||||
| Drives_construct | WBCnstr00037223 | ||||||||
| Construct_product | WBCnstr00037223 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (165) | |||||||||
| Map_info | Map | V | Position | 7.51429 | Error | 0.006122 | |||
| Positive | Positive_clone | Y75B12B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK520 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | signal_peptide | ||||||||
| [Page AM] From partial Est sequence CEESN11F. Is transpliced by SL-1. Isolated from mixed stage cDNA using SL1, and known 3' seq from CEESN11F. | |||||||||
| [Page AM] Have been unable to accurately map this gene to the YAC grid- as it cross-hybridises with the other highly homologous gene. | |||||||||
| PPIase or cyclophilin, EC 5.2.1.8 | |||||||||
| This gene has been renamed with approval of the CGC (cyp-7->cyn-7) | Person_evidence | WBPerson466 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
