WormBase Tree Display for Gene: WBGene00000883
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WBGene00000883 | SMap | S_parent | Sequence | Y75B12B | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | cyn-7 | Person_evidence | WBPerson466 | |||
Sequence_name | Y75B12B.2 | ||||||
Molecular_name | Y75B12B.2 | ||||||
Y75B12B.2.1 | |||||||
CE20371 | |||||||
Other_name | cyp-7 | Person_evidence | WBPerson466 | ||||
CELE_Y75B12B.2 | Accession_evidence | NDB | BX284605 | ||||
Public_name | cyn-7 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cyn | ||||||
Allele (26) | |||||||
Legacy_information | [C.elegansII] NMK. Cyclophilin family. Signal peptide. [TP] | ||||||
Strain | WBStrain00032910 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (11) | |||||||
Ortholog (63) | |||||||
Paralog (18) | |||||||
Structured_description | Concise_description | cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays. | Paper_evidence | WBPaper00002472 | |||
WBPaper00004651 | |||||||
WBPaper00026884 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 20 Mar 2007 00:00:00 | ||||||
Automated_description | Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||
DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
Molecular_info | Corresponding_CDS | Y75B12B.2 | |||||
Corresponding_transcript | Y75B12B.2.1 | ||||||
Other_sequence (63) | |||||||
Associated_feature | WBsf653438 | ||||||
WBsf653439 | |||||||
WBsf977373 | |||||||
WBsf977374 | |||||||
WBsf235037 | |||||||
Experimental_info | RNAi_result | WBRNAi00111702 | Inferred_automatically | RNAi_primary | |||
WBRNAi00001940 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00058420 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027817 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00083853 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00083670 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021427 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076846 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1064 | ||||||
Expr1022229 | |||||||
Expr1030548 | |||||||
Expr1161841 | |||||||
Expr2010675 | |||||||
Expr2028915 | |||||||
Drives_construct | WBCnstr00037223 | ||||||
Construct_product | WBCnstr00037223 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (195) | |||||||
Interaction (165) | |||||||
Map_info | Map | V | Position | 7.51429 | Error | 0.006122 | |
Positive | Positive_clone | Y75B12B | Inferred_automatically | From sequence, transcript, pseudogene data | |||
ZK520 | |||||||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | signal_peptide | ||||||
[Page AM] From partial Est sequence CEESN11F. Is transpliced by SL-1. Isolated from mixed stage cDNA using SL1, and known 3' seq from CEESN11F. | |||||||
[Page AM] Have been unable to accurately map this gene to the YAC grid- as it cross-hybridises with the other highly homologous gene. | |||||||
PPIase or cyclophilin, EC 5.2.1.8 | |||||||
This gene has been renamed with approval of the CGC (cyp-7->cyn-7) | Person_evidence | WBPerson466 | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |