WormBase Tree Display for Gene: WBGene00006537
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| WBGene00006537 | SMap | S_parent | Sequence | C36E8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tbb-2 | |||||||
| Sequence_name | C36E8.5 | ||||||||
| Molecular_name | C36E8.5 | ||||||||
| C36E8.5.1 | |||||||||
| CE00913 | |||||||||
| Other_name | TUBB8 | ||||||||
| rot-2 | CGC_data_submission | ||||||||
| CELE_C36E8.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | tbb-2 | ||||||||
| DB_info | Database | AceView | gene | 3F106 | |||||
| WormQTL | gene | WBGene00006537 | |||||||
| WormFlux | gene | WBGene00006537 | |||||||
| NDB | locus_tag | CELE_C36E8.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006537|UniProtKB=P52275 | |||||||
| family | PTHR11588 | ||||||||
| NCBI | gene | 175519 | |||||||
| RefSeq | protein | NM_065405.8 | |||||||
| SwissProt | UniProtAcc | P52275 | |||||||
| UniProt_GCRP | UniProtAcc | P52275 | |||||||
| OMIM | gene | 602661 | |||||||
| 616768 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tbb | ||||||||
| Allele (24) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes beta tubulin. [NW] | ||||||||
| [Schnabel H] maternal-effect embryonic lethal with defect in rotation of centrosome pair and associated pronuclei before first cleavage | |||||||||
| Strain (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (70) | |||||||||
| Paralog (16) | |||||||||
| Structured_description | Concise_description | tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. | Paper_evidence (11) | ||||||
| Person_evidence | WBPerson399 | ||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in meiotic spindle organization. Located in spindle microtubule. Expressed in several structures, including germ line; gonad; oocyte; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Is an ortholog of several human genes including TUBB3 (tubulin beta 3 class III); TUBB6 (tubulin beta 6 class V); and TUBB8B (tubulin beta 8B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0090137 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20772) | ||||
| DOID:0081017 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20772) | ||||||
| EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20773) | ||||||
| Molecular_info | Corresponding_CDS | C36E8.5 | |||||||
| Corresponding_transcript | C36E8.5.1 | ||||||||
| Other_sequence (265) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (50) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002578 | ||||||||
| WBCnstr00034316 | |||||||||
| WBCnstr00039276 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000703 | ||||||||
| WBAntibody00000712 | |||||||||
| WBAntibody00002338 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (206) | |||||||||
| Interaction (328) | |||||||||
| Map_info | Map | III | Position | -4.0282 | Error | 0.006633 | |||
| Positive | Positive_clone | C36E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| NW#B8 | |||||||||
| Mapping_data | Multi_point | 4052 | |||||||
| 4053 | |||||||||
| 4627 | |||||||||
| 5482 | |||||||||
| 5499 | |||||||||
| Reference (92) | |||||||||
| Remark | Sequence connection updated based on email from Chenggang Lu | ||||||||
| cgc3909 linked tbb-2 to B0272.1, which is not approved by CGC | CGC_data_submission | ||||||||
| Method | Gene |
