WormBase Tree Display for Gene: WBGene00004134
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| WBGene00004134 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | myrf-1 | Person_evidence | WBPerson7150 | |||||
| Sequence_name | F59B10.1 | ||||||||
| Molecular_name | F59B10.1 | ||||||||
| F59B10.1.1 | |||||||||
| CE36940 | |||||||||
| Other_name | pqn-47 | Person_evidence | WBPerson625 | ||||||
| CELE_F59B10.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | myrf-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Dec 2014 15:51:18 | WBPerson2970 | Name_change | CGC_name | myrf-1 | ||||
| Other_name | pqn-47 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | myrf | ||||||||
| Allele (84) | |||||||||
| Possibly_affected_by | WBVar02157207 | ||||||||
| Strain | WBStrain00037532 | ||||||||
| WBStrain00037768 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00008999 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | myrf-1 encodes a protein with a glutamine/asparagine-rich domain, orthologous to human MYRF (myelin regulatory factor); in C. elegans, MYRF-1 activity is required for regulation of the molting cycle, specifically the completion of larval molts and cessation of molting in reproductively mature adult animals; a MYRF-1::GFP fusion protein is expressed in a wide variety of cells and tissues, including neurons, secretory cells, and hypodermal seam cells, but is not seen in the hyp7 syncytial hypodermis; expression begins in the comma stage of embryogenesis and persists through adulthood; full length C. elegans MYRF-1::GFP localizes to the cytoplasm where it partially overlaps with the endoplasmic reticulum; MYRF-1 contains a well-conserved paralog in the C. elegans genome, MYRF-2, encoded by F21A10.2. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005487 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00012811 | |||||||||
| WBPaper00040293 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Dec 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode larval development. Located in basal part of cell and endoplasmic reticulum. Expressed in several structures, including ciliated neurons; excretory duct; gonad; pharyngeal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; and eye disease (multiple). Is an ortholog of human MYRFL (myelin regulatory factor like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||
| DOID:3827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||||
| DOID:9834 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||||
| DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||||
| Molecular_info | Corresponding_CDS | F59B10.1 | |||||||
| Corresponding_CDS_history | F59B10.1:wp127 | ||||||||
| Corresponding_transcript | F59B10.1.1 | ||||||||
| Other_sequence | CR10282 | ||||||||
| CR10281 | |||||||||
| CRC03559_1 | |||||||||
| ACC07624_1 | |||||||||
| SRC00534_1 | |||||||||
| EY470006.1 | |||||||||
| Tcol_isotig21011 | |||||||||
| SR01712 | |||||||||
| Name_isotig07910 | |||||||||
| JI164614.1 | |||||||||
| Associated_feature (15) | |||||||||
| Transcription_factor | WBTranscriptionFactor000563 | ||||||||
| Experimental_info | RNAi_result (46) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00004111 | ||||||||
| WBCnstr00009459 | |||||||||
| WBCnstr00009460 | |||||||||
| WBCnstr00014243 | |||||||||
| WBCnstr00014244 | |||||||||
| WBCnstr00019909 | |||||||||
| WBCnstr00037934 | |||||||||
| Construct_product | WBCnstr00009460 | ||||||||
| WBCnstr00014243 | |||||||||
| WBCnstr00014244 | |||||||||
| WBCnstr00037934 | |||||||||
| Regulate_expr_cluster | WBPaper00061377:MYRF-1_interacting | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (679) | |||||||||
| Anatomy_function | WBbtf1093 | ||||||||
| WBbtf1094 | |||||||||
| WBbtf1095 | |||||||||
| Map_info | Map | II | Position | 2.9838 | Error | 0.041984 | |||
| Positive | Positive_clone | F59B10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
