WormBase Tree Display for Gene: WBGene00001898

WBGene00001898 SMap: S_parent: Sequence: M163
  Identity: Version: 2
    Name: CGC_name: his-24 Person_evidence: WBPerson160
      Sequence_name: M163.3
      Molecular_name: M163.3
        M163.3.1
        CE12450
      Other_name: HH1
        H1.1 Paper_evidence: WBPaper00004630
        Histone H1.1 Paper_evidence: WBPaper00053345
        CELE_M163.3 Accession_evidence: NDB BX284606
      Public_name: his-24
    DB_info: Database: AceView gene XP109
        WormQTL gene WBGene00001898
        WormFlux gene WBGene00001898
        NDB locus_tag CELE_M163.3
        Panther gene CAEEL|WormBase=WBGene00001898|UniProtKB=P10771
          family PTHR11467
        NCBI gene 181545
        RefSeq protein NM_078009.7
        SwissProt UniProtAcc P10771
        UniProt_GCRP UniProtAcc P10771
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 12 Nov 2010 10:24:40 WBPerson2970 Name_change: Other_name: H1.1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele (33)
    Legacy_information: [C.elegansII] NMK. Histone type H1. Contains intron, encodes polyadenylated RNA. [Sanicola et al. 1990]
    Strain: WBStrain00031772
      WBStrain00034782
      WBStrain00034807
      WBStrain00006458
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (80)
    Paralog: WBGene00001852 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001853 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001854 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001856 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001857 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: his-24 encodes one of eight C. elegans H1 linker histones; HIS-24, along with the histone deacetylase SIR-2.1 and the Enhancer of zeste E(Z) ortholog MES-2, plays a key role in heterochromatin regulation and thus, in regulation of fertility and embryonic development; specifically, HIS-24 and SIR-2.1 are essential for maintenance of the histone H3K27me3 mark at subtelomeric regions in the C. elegans germ line; HIS-24 interacts specifically with the H3 K27 region, either when unmodified or when in the trimethylated (me3) state; HIS-24 is ubiquitously expressed and localizes to nuclei; in addition, in germ cells, the majority of HIS-24 localizes to the cytoplasm, in a manner dependent upon SIR-2.1 and MES proteins. Paper_evidence: WBPaper00004630
            WBPaper00028983
            WBPaper00033091
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Nov 2010 00:00:00
      Automated_description: Enables H3K27me3 modified histone binding activity. Involved in defense response to Gram-positive bacterium and negative regulation of gene expression. Located in chromosome, telomeric region; cytoplasm; and nucleus. Expressed in several structures, including germ line and gonad. Is an ortholog of human H1-0 (H1.0 linker histone) and H1-8 (H1.8 linker histone). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: M163.3
    Corresponding_transcript: M163.3.1
    Other_sequence (76)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00090698 Inferred_automatically: RNAi_primary
      WBRNAi00017226 Inferred_automatically: RNAi_primary
      WBRNAi00089638 Inferred_automatically: RNAi_primary
      WBRNAi00027719 Inferred_automatically: RNAi_primary
      WBRNAi00089608 Inferred_automatically: RNAi_primary
      WBRNAi00050989 Inferred_automatically: RNAi_primary
      WBRNAi00076026 Inferred_automatically: RNAi_primary
      WBRNAi00076031 Inferred_automatically: RNAi_primary
      WBRNAi00064599 Inferred_automatically: RNAi_primary
      WBRNAi00076030 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00000408
      WBCnstr00000430
      WBCnstr00002522
      WBCnstr00007280
      WBCnstr00009451
      WBCnstr00013533
      WBCnstr00015453
      WBCnstr00015912
      WBCnstr00036616
    Construct_product (293)
    Regulate_expr_cluster: WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
    Antibody: WBAntibody00000355
      WBAntibody00001210
      WBAntibody00002298
    Microarray_results (26)
    Expression_cluster (392)
    Interaction (157)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: X Position: 16.7093 Error: 0.005353
    Positive: Positive_clone: LCEH1A
        M163 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene