WormBase Tree Display for Gene: WBGene00003920
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| WBGene00003920 | SMap | S_parent | Sequence | M117 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | par-5 | Person_evidence | WBPerson314 | |||||
| Sequence_name | M117.2 | ||||||||
| Molecular_name | M117.2a | ||||||||
| M117.2a.1 | |||||||||
| CE06200 | |||||||||
| M117.2b | |||||||||
| CE48396 | |||||||||
| M117.2a.2 | |||||||||
| M117.2a.3 | |||||||||
| M117.2a.4 | |||||||||
| M117.2b.1 | |||||||||
| Other_name | ftt-1 | ||||||||
| CELE_M117.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | par-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | par | ||||||||
| Allele (23) | |||||||||
| Legacy_information | [C.elegansII] it55 : maternal effect lethal; 2nd cleavage spindles transverse, asters spherical (resembles Par-2); most embryos lack gut granules. OA1. [Morton et al. 1992; KK] | ||||||||
| [C.elegansII] NMK. Encodes predicted protein 78% identicalto Drosophila and bovine 14-3-3 proteins. [Wang and Shakes 1994; DS] | |||||||||
| Strain | WBStrain00023556 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00001502 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010919 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | PAR-5 encodes one of two C. elegans 14-3-3 proteins; par-5 is essential for early embryonic development, particularly for early embryonic asymmetry; PAR-5 also functions in a Wnt/MAPK signaling pathway to regulate the nuclear level of the POP-1/TCF transcription factor; PAR-5 has been shown to physically interact with a number of proteins, including those involved in G protein signaling pathways and regulation of adult lifespan. | Paper_evidence | WBPaper00005079 | |||||
| WBPaper00006460 | |||||||||
| WBPaper00027195 | |||||||||
| WBPaper00027682 | |||||||||
| WBPaper00027763 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Mar 2011 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including cellular localization; determination of adult lifespan; and first cell cycle pseudocleavage. Located in cell cortex and nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:8719 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||||
| DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12855) | ||||||
| DOID:2101 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||||
| Molecular_info | Corresponding_CDS | M117.2a | |||||||
| M117.2b | |||||||||
| Corresponding_transcript | M117.2a.1 | ||||||||
| M117.2a.2 | |||||||||
| M117.2a.3 | |||||||||
| M117.2a.4 | |||||||||
| M117.2b.1 | |||||||||
| Other_sequence (92) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (81) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000448 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (193) | |||||||||
| Interaction (448) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | IV | Position | 5.3063 | Error | 0.001806 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C38H7 | |||||||
| M117 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 3263 | |||||||
| 3810 | |||||||||
| Multi_point | 1262 | ||||||||
| Pos_neg_data | 3264 | ||||||||
| 3265 | |||||||||
| 3266 | |||||||||
| 6749 | |||||||||
| 8178 | |||||||||
| Reference (105) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark | The ftt-1 gene was merged into par-5 following advice from J .Hodgkin (evidence from [Morton DG, Shakes DC, Kemphues K]). krb 02/03/04 | ||||||||
| Sequence connection from [Morton DG, Shakes DC, Kemphues K], 02/06/13 krb. | |||||||||
| Method | Gene |
