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WormBase Tree Display for Gene: WBGene00002978

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Name Class

WBGene00002978SMapS_parentSequenceY105E8B
IdentityVersion1
NameCGC_namelev-11Person_evidenceWBPerson368
Sequence_nameY105E8B.1
Molecular_name (58)
Other_nametmy-1
Y105E8B.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CeTMPaper_evidenceWBPaper00005168
WBPaper00032338
CELE_Y105E8B.1Accession_evidenceNDBBX284601
Public_namelev-11
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlev
Reference_alleleWBVar00275207
Allele (205)
Legacy_informationx12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
See also e1724
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
StrainWBStrain00002959
WBStrain00033515
WBStrain00033518
WBStrain00033524
WBStrain00040917
WBStrain00040918
WBStrain00004923
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (47)
Structured_descriptionConcise_descriptionlev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.Paper_evidenceWBPaper00002748
WBPaper00004944
Curator_confirmedWBPerson1823
WBPerson1843
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_modelDOID:0111597Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0110926Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0110457Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110932Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0080326Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0080102Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
Molecular_infoCorresponding_CDS (19)
Corresponding_CDS_historyY105E8B.1b:wp62
Y105E8B.1b:wp114
Y105E8B.1c:wp62
Corresponding_transcript (20)
Other_sequence (913)
Associated_feature (35)
Experimental_infoRNAi_result (31)
Expr_pattern (15)
Drives_construct (12)
Construct_productWBCnstr00010369
WBCnstr00012505
WBCnstr00016244
WBCnstr00041176
AntibodyWBAntibody00000099
WBAntibody00000422
WBAntibody00000423
WBAntibody00000472
Microarray_results (61)
Expression_cluster (281)
Interaction (175)
WBProcessWBbiopr:00000006
Map_infoMapIPosition25.8125Error0.018971
Well_ordered
PositivePositive_cloneY105E8BInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_data2_point209
213
214
327
5106
6076
Multi_point (11)
Pos_neg_data (13)
Reference (89)
RemarkData extracted from Williams & Waterston 1994
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02
MethodGene