[C.elegansII] NMK. Encodes member of nuclear hormone receptor superfamily (pka crf-2). 50% identity to mouse thyroid hormone receptor in zinc finger region. NHR-2 present in embryonic nuclei at 2 cellstage, ubiquitous until gastrulation, later diminishes; transcript in maternal germline. Antisense expression leads to posterior necrosis in L4, adult. [Seydoux and Fire 1994; AE; GR]
nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis.
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including Cpaaaa; Cpaaap; Cpaapa; Cpaapp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); congenital nongoitrous hypothyroidism 6; and cystic fibrosis. Is an ortholog of human PPARA (peroxisome proliferator activated receptor alpha) and THRA (thyroid hormone receptor alpha).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.