WormBase Tree Display for Gene: WBGene00003670
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| WBGene00003670 | Evidence | Paper_evidence | WBPaper00003754 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | H10E21 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhr-80 | Person_evidence | WBPerson600 | |||||
| Sequence_name | H10E21.3 | ||||||||
| Molecular_name | H10E21.3a | ||||||||
| H10E21.3a.1 | |||||||||
| CE28733 | |||||||||
| H10E21.3b | |||||||||
| CE19488 | |||||||||
| H10E21.3b.1 | |||||||||
| Other_name | CELE_H10E21.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | nhr-80 | ||||||||
| DB_info | Database | AceView | gene | 3A630 | |||||
| WormQTL | gene | WBGene00003670 | |||||||
| WormFlux | gene | WBGene00003670 | |||||||
| NDB | locus_tag | CELE_H10E21.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003670|UniProtKB=Q8ITW8 | |||||||
| family | PTHR46011 | ||||||||
| NCBI | gene | 175167 | |||||||
| RefSeq | protein | NM_064725.7 | |||||||
| NM_181901.2 | |||||||||
| SwissProt | UniProtAcc | Q8ITW8 | |||||||
| TREEFAM | TREEFAM_ID | TF321941 | |||||||
| UniProt_GCRP | UniProtAcc | Q8ITW8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (234) | |||||||||
| Strain | WBStrain00008405 | ||||||||
| WBStrain00034506 | |||||||||
| WBStrain00034508 | |||||||||
| WBStrain00034509 | |||||||||
| WBStrain00004023 | |||||||||
| WBStrain00030244 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (30) | |||||||||
| Paralog (225) | |||||||||
| Structured_description | Concise_description | nhr-80 encodes a nuclear hormone receptor, expressed in the intestine,that regulates expression of the delta-9 desaturases FAT-5/-6/-7, andthus regulates fatty acid metabolism; NHR-80 is fully required for anyexpression of FAT-7, full expression of FAT-5/-6, viability in theabsence of FAT-6, and transcriptional hyperactivation of fat-7 in theabsence of FAT-6, and for a fully normal adult lifespan; nhr-80 isexpressed robustly in the intestine during larval and adult stages ofdevelopment, with some expression also seen in head muscles; nhr-80 isspecific to nematodes, being a divergent ortholog of HNF4 with manyparalogs in C. elegans; nhr-80(tm1011) mutants, like nhr-49 mutants,have an increased ration of saturated 18:0 fatty acids tomonounsaturated 18:1 ones (4.6 instead of 2.2); nhr-80(tm1011) mutantsare viable and fertile and have no increase in fat storage, but doublefat-6(tm331);nhr-80(tm1011) mutants, (or fat-6(tm331) mutants subjectedto nhr-80(RNAi), are synthetically lethal unless cultured on mediasupplemented with desaturated fatty acids. | Paper_evidence | WBPaper00003754 | |||||
| WBPaper00027749 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan; positive regulation of metabolic process; and post-embryonic development. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | H10E21.3a | |||||||
| H10E21.3b | |||||||||
| Corresponding_transcript | H10E21.3a.1 | ||||||||
| H10E21.3b.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf650778 | ||||||||
| WBsf226071 | |||||||||
| Transcription_factor | WBTranscriptionFactor000724 | ||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern | Expr1184 | ||||||||
| Expr9203 | |||||||||
| Expr1028389 | |||||||||
| Expr1153088 | |||||||||
| Expr2014232 | |||||||||
| Expr2032473 | |||||||||
| Drives_construct | WBCnstr00008319 | ||||||||
| WBCnstr00010136 | |||||||||
| WBCnstr00013793 | |||||||||
| WBCnstr00018585 | |||||||||
| WBCnstr00035958 | |||||||||
| Construct_product | WBCnstr00008319 | ||||||||
| WBCnstr00010136 | |||||||||
| WBCnstr00013793 | |||||||||
| WBCnstr00016839 | |||||||||
| WBCnstr00018585 | |||||||||
| WBCnstr00035958 | |||||||||
| Regulate_expr_cluster | WBPaper00040998:nhr-80_regulated | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (27) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | III | Position | -27.2207 | Error | 0.030731 | |||
| Positive | Positive_clone | H10E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| H10E21 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference (37) | |||||||||
| Picture | WBPicture0000013097 | ||||||||
| WBPicture0000013098 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
