WormBase Tree Display for Gene: WBGene00003704
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| WBGene00003704 | SMap | S_parent | Sequence | Y45G5AM | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhr-114 | Person_evidence | WBPerson600 | |||||
| Sequence_name | Y45G5AM.1 | ||||||||
| Molecular_name | Y45G5AM.1a | ||||||||
| Y45G5AM.1a.1 | |||||||||
| CE33735 | |||||||||
| Y45G5AM.1d | |||||||||
| CE51628 | |||||||||
| Y45G5AM.1b | |||||||||
| Y45G5AM.1c | |||||||||
| Y45G5AM.1d.1 | |||||||||
| Other_name | CELE_Y45G5AM.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | nhr-114 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (76) | |||||||||
| Strain | WBStrain00036852 | ||||||||
| WBStrain00007427 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (27) | |||||||||
| Paralog (216) | |||||||||
| Structured_description | Concise_description | nhr-114 encodes, by alternative splicing, two isoforms of a nuclear hormone receptor that specifically binds GPA-13 in yeast two-hybrid assays; the interaction of NHR-114 with GPA-13 is independent of whether GPA-13 is constitutively activated or not; NHR-114 is expressed in intestine (and weakly in hypodermal cells), with mainly nuclear localization. | Paper_evidence | WBPaper00006194 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on S-adenosylmethionine cycle. Located in nucleus. Expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human NR1H3 (nuclear receptor subfamily 1 group H member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:13001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
| DOID:7693 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||||
| Molecular_info | Corresponding_CDS | Y45G5AM.1a | |||||||
| Y45G5AM.1d | |||||||||
| Corresponding_CDS_history | Y45G5AM.1:wp97 | ||||||||
| Y45G5AM.1b:wp253 | |||||||||
| Corresponding_transcript | Y45G5AM.1b | ||||||||
| Y45G5AM.1c | |||||||||
| Y45G5AM.1a.1 | |||||||||
| Y45G5AM.1d.1 | |||||||||
| Other_sequence | CSC00551_1 | ||||||||
| CBC02885_1 | |||||||||
| CRC06189_1 | |||||||||
| CBC03000_1 | |||||||||
| HC07024 | |||||||||
| CBC06116_1 | |||||||||
| FD514251.1 | |||||||||
| CR10753 | |||||||||
| CGC01249_1 | |||||||||
| Associated_feature | WBsf646747 | ||||||||
| WBsf646748 | |||||||||
| WBsf1019469 | |||||||||
| WBsf231647 | |||||||||
| WBsf231648 | |||||||||
| WBsf231649 | |||||||||
| WBsf231650 | |||||||||
| Transcription_factor | WBTranscriptionFactor000567 | ||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr2750 | ||||||||
| Expr10759 | |||||||||
| Expr1028755 | |||||||||
| Expr1031725 | |||||||||
| Expr1160103 | |||||||||
| Expr2014012 | |||||||||
| Expr2032252 | |||||||||
| Drives_construct | WBCnstr00010930 | ||||||||
| Construct_product | WBCnstr00010930 | ||||||||
| Regulate_expr_cluster | WBPaper00042194:nhr-114(RNAi)_downregulated | ||||||||
| WBPaper00042194:nhr-114(RNAi)_upregulated | |||||||||
| WBPaper00064539:nhr-114(gk849)_downregulated | |||||||||
| WBPaper00064539:nhr-114(gk849)_upregulated | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (219) | |||||||||
| Interaction (89) | |||||||||
| Anatomy_function | WBbtf0599 | ||||||||
| WBbtf0600 | |||||||||
| Map_info | Map | V | Position | -6.3139 | Error | 0.012518 | |||
| Positive | Positive_clone | Y45G5AM | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | yk709c2 - EST sequence gives exact hit to both this orf and C27C7.8 - which is actual source? tentatively assigned to ZK1025.9 since C27C7.8 appears to be partial gene (no obvious NR DNA binding domain sequences) - EST clone has DBD, so is ZK1025.9 [Sluder A][030102 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
