dpy-17 encodes a cuticle collagen; during development, dpy-17 activity is required for normal body morphology, hermaphrodite tail development, and outgrowth of posterior canal cell processes; genetic and immunofluorescence studies suggest that extracellular assembly of DPY-17 and the essential SQT-3 cuticle collagen is interdependent, as loss of dpy-17 activity results in intracellular retention of SQT-3 and dpy-17(gf) mutations suppress mutations in dpy-31, which encodes a zinc-metalloprotease predicted to affect C-terminal proteolytic maturation of SQT-3.
Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. Used to study Marfan syndrome.
[Smardon A] dpy-17(e164) rescued by sEx271 [F54D8 + pCes1943{rol-6(su1006dm)}]. F54D8.1 encodes predicted protein with C-term similarity to sqt-1 collagen, therefore candidate for dpy-17.