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WormBase Tree Display for Gene: WBGene00006789

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Name Class

WBGene00006789SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_nameunc-54Person_evidenceWBPerson261
Sequence_nameF11C3.3
Molecular_nameF11C3.3
F11C3.3.1
CE09349
Other_namemyo-4
CELE_F11C3.3Accession_evidenceNDBBX284601
Public_nameunc-54
DB_infoDatabaseAceViewgene1P454
WormQTLgeneWBGene00006789
WormFluxgeneWBGene00006789
NDBlocus_tagCELE_F11C3.3
PanthergeneCAEEL|WormBase=WBGene00006789|UniProtKB=P02566
familyPTHR45615
NCBIgene259839
RefSeqproteinNM_061195.7
SwissProtUniProtAccP02566
UniProt_GCRPUniProtAccP02566
OMIMgene160710
160720
160740
160741
160760
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (386)
Legacy_informationStructural gene for major body wall myosin heavy chain. Reference null allele e190 : limp paralysed phenotype at all stages larvae can move slightly more than adults Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. NA (recessive) > 50 including e1108amber; e1301ts; e675sd and s291 (in frame internal deletion mutants with heavy chain fragment behavioral phenotype almost paralysed slight twitcher); also Tc1 insertion mutants; etc. Also unusual suppressor alleles (NA > 15) e.g. s74 : dominant suppressor of unc-22(s12) no other dominant phenotype recessive phenotype slow stiff normal muscle ultrastructure; alteration in S1 portion of protein. Also Class 3 (dominant) alleles reference allele e1152sd : severe rigid paralysis small; e1152/+ paralysed weaker phenotype. ES3 ME0. NA (dominant) > 10 : e1153 n489 etc.; resemble e1152 or more severe recessive lethal. Intragenic revertants have Class 1 phenotypes.
See unc-54.
See also e569, e576, e651, e675, e843, e903, e1008, e1009, e1021, e1092, e1108, e1115, e1152, e1153, e1157, e1168, e1201, e1213, e1219, e1223, e1257, e1258, e1273, e1274, e1300, e1301, e1311, e1315, e1328, e1360, e1419, e1420, n325, n326, n327, n489, n794, r274, r308, r322, r323, r327, r360, s74, s75, s76, s77, s78, s95, s291, s409, s411
[C.elegansII] e190 : limp paralysed phenotype at all stages; larvae can move slightly more than adults; Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small;e1152/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974; McLachlan and Karn 1982;Dibb et al. 1989; Bejsovec and Anderson 1990; TR; RW]
StrainWBStrain00000182
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RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (82)
Paralog (21)
Structured_descriptionConcise_descriptionunc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically.Paper_evidenceWBPaper00000232
WBPaper00000647
WBPaper00001014
WBPaper00005299
WBPaper00005940
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (30)
Molecular_infoCorresponding_CDSF11C3.3
Corresponding_transcriptF11C3.3.1
Other_sequence (386)
Associated_feature (32)
Experimental_infoRNAi_result (12)
Expr_pattern (15)
Drives_construct (151)
Construct_productWBCnstr00011688
WBCnstr00011704
WBCnstr00013869
WBCnstr00015881
WBCnstr00018819
WBCnstr00034149
Antibody (11)
Microarray_results (22)
Expression_cluster (308)
Interaction (231)
WBProcessWBbiopr:00000040
Map_infoMapIPosition27.9607Error0.002243
Well_ordered
PositiveInside_rearreDf3
eDf10
dxDf2
Positive_cloneF11C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
SG25/36
Mapping_data (3)
Landmark_gene
Reference (599)
Remarkunc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97
MethodGene