ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which definesone of seven paralogous families of sterol sensing domain (SSD)proteins; PTR-2 is required for cytokinesis in somatic cells, but not inthe germline (the converse of PTC-1's function); PTR-2 is partiallyrequired for normal molting from L4 to adult stages; PTR-2 is alsorequired for normal male tail development, growth to full size,locomotion, and viability.
Predicted to enable transmembrane transporter activity. Involved in mitotic cytokinesis and molting cycle. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.