WormBase Tree Display for Gene: WBGene00004230
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| WBGene00004230 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T21H3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ptr-16 | Person_evidence | WBPerson349 | |||||
| Sequence_name | T21H3.2 | ||||||||
| Molecular_name | T21H3.2a | ||||||||
| T21H3.2a.1 | |||||||||
| CE50972 | |||||||||
| T21H3.2b | |||||||||
| CE50961 | |||||||||
| T21H3.2b.1 | |||||||||
| Other_name | CELE_T21H3.2 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | ptr-16 | ||||||||
| DB_info | Database | AceView | gene | 5B651 | |||||
| WormQTL | gene | WBGene00004230 | |||||||
| WormFlux | gene | WBGene00004230 | |||||||
| NDB | locus_tag | CELE_T21H3.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004230|UniProtKB=A0A0K3ASC2 | |||||||
| family | PTHR10796 | ||||||||
| NCBI | gene | 191750 | |||||||
| RefSeq | protein | NM_001313273.5 | |||||||
| NM_001313272.3 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AV55 | |||||||
| A0A0K3ASC2 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A0K3ASC2 | |||||||
| OMIM | gene | 300828 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ptr | ||||||||
| Allele (190) | |||||||||
| Strain | WBStrain00037812 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00000969 | ||||||||
| 00000970 | |||||||||
| 00000971 | |||||||||
| 00000972 | |||||||||
| 00000973 | |||||||||
| 00112522 | |||||||||
| Ortholog (40) | |||||||||
| Paralog (30) | |||||||||
| Structured_description | Concise_description | ptr-16 encodes a nematode-specific member of the sterol sensing domain(SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) andhuman PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-16is partially required for normal molting from L2 to L3 larval stages;however, PTR-16 and PTR-1 together are strongly required for bothmolting and viability, with double ptr-1/-16 RNAi animals showingpronounced molting defects and lethality; PTR-16 is also required fornormal growth to full size and locomotion. | Paper_evidence | WBPaper00026841 | |||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 08 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to be involved in endocytosis and molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1); PTCHD3 (patched domain containing 3 (gene/pseudogene)); and PTCHD4 (patched domain containing 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26392) | ||||
| Molecular_info | Corresponding_CDS | T21H3.2a | |||||||
| T21H3.2b | |||||||||
| Corresponding_CDS_history | T21H3.2:wp231 | ||||||||
| T21H3.2:wp249 | |||||||||
| Corresponding_transcript | T21H3.2a.1 | ||||||||
| T21H3.2b.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf661120 | ||||||||
| WBsf999266 | |||||||||
| WBsf231394 | |||||||||
| WBsf231395 | |||||||||
| WBsf231396 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00018989 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00076924 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053762 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076956 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077029 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1014389 | ||||||||
| Expr1032082 | |||||||||
| Expr1157312 | |||||||||
| Expr2015159 | |||||||||
| Expr2033397 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (192) | |||||||||
| Interaction (219) | |||||||||
| Map_info | Map | V | Position | -19.8499 | Error | 0.000282 | |||
| Positive | Positive_clone | T21H3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004265 | ||||||||
| WBPaper00024393 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064105 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
