WormBase Tree Display for Gene: WBGene00006792

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WBGene00006792	SMap	S_parent	Sequence	T06H11
	Identity	Version	3
		Name	CGC_name	unc-58	Person_evidence	WBPerson261
			Sequence_name	T06H11.1
			Molecular_name (21)
			Other_name	twk-18	CGC_data_submission
				CELE_T06H11.1	Accession_evidence	NDB	BX284606
			Public_name	unc-58
		DB_info	Database	AceView	gene	XK722
				WormQTL	gene	WBGene00006792
				WormFlux	gene	WBGene00006792
				NDB	locus_tag	CELE_T06H11.1
				Panther	gene	CAEEL\|WormBase=WBGene00006792\|UniProtKB=Q22271
					family	PTHR11003
				NCBI	gene	181224
				RefSeq	protein	NM_171758.5
						NM_001373460.3
						NM_001373459.2
						NM_001373458.4
						NM_001373457.2
						NM_001373456.2
						NM_171759.6
				SwissProt	UniProtAcc	Q22271
				TrEMBL	UniProtAcc	A0A4V0IKI8
						A0A4V0IL39
						A0A4V0IKM3
						A0A4V0INP7
						A0A4V0INX3
				UniProt_GCRP	UniProtAcc	Q22271
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:43	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	20 May 2019 15:21:47	WBPerson4025	Event	Acquires_merge	WBGene00011553
				3	20 May 2019 15:21:47	WBPerson4025	Event	Acquires_merge	WBGene00011552
			Acquires_merge	WBGene00011553
				WBGene00011552
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143382
		Allele	WBVar00143382	Inferred_automatically	From strain object: CB2842
					From strain object: CB3816
					From strain object: CB665
					From strain object: DR286
					From strain object: MT814
					From strain object: MT831
			WBVar00144573	Inferred_automatically	From strain object: CB2842
			WBVar00089549	Inferred_automatically	From strain object: MT1089
					From strain object: MT2712
			WBVar00090086	Inferred_automatically	From strain object: MT2712
			WBVar00089389	Inferred_automatically	From strain object: MT814
			WBVar00089395	Inferred_automatically	From strain object: MT831
			WBVar00089393
			WBVar00089388
			WBVar00089394
			WBVar00143916
			WBVar00143192
			WBVar00089391
			WBVar00143478
			WBVar00143461
			WBVar00089392
			WBVar00143385
			WBVar00089550
			WBVar00089390
			WBVar00143384
			WBVar00514404
			WBVar01178854
			WBVar00514405
			WBVar01178855
			WBVar01527598
			WBVar00514406
			WBVar00062179
			WBVar01527599
			WBVar01178856
			WBVar00082172
			WBVar00514407
			WBVar01178857
			WBVar00082173
			WBVar01527600
			WBVar00514408
			WBVar01178858
			WBVar01527601
			WBVar00082175
			WBVar01178859
			WBVar00082177
			WBVar01527602
			WBVar00062184
			WBVar00514409
			WBVar01178860
			WBVar00082181
			WBVar00514410
			WBVar00514411
			WBVar00062189
			WBVar00082183
			WBVar01178861
			WBVar00082184
			WBVar01178862
			WBVar00514412
			WBVar00062194
			WBVar01178863
			WBVar00082185
			WBVar00514413
			WBVar00514414
			WBVar01178864
			WBVar00082187
			WBVar00514415
			WBVar00082188
			WBVar01178865
			WBVar00082189
			WBVar00514416
			WBVar01178866
			WBVar01178867
			WBVar00514417
			WBVar00514418
			WBVar01981204
			WBVar01178868
			WBVar00514419
			WBVar01178869
			WBVar00514420
			WBVar01178870
			WBVar00514421
			WBVar01178871
			WBVar01178872
			WBVar00514422
			WBVar00514423
			WBVar01178873
			WBVar00514424
			WBVar01178874
			WBVar01178875
			WBVar00514425
			WBVar01178876
			WBVar00514426
			WBVar01178877
			WBVar00514427
			WBVar01178878
			WBVar00514428
			WBVar01178879
			WBVar00514429
			WBVar01178880
			WBVar00514430
			WBVar00514431
			WBVar01178881
			WBVar00514432
			WBVar01786908
			WBVar01178882
			WBVar01786909
			WBVar01178883
			WBVar00514433
			WBVar01786910
			WBVar00514434
			WBVar01178884
			WBVar01786911
			WBVar01178885
			WBVar00514435
			WBVar00514436
			WBVar01178886
			WBVar01786912
			WBVar01178887
			WBVar00514437
			WBVar01816775
			WBVar01759011
			WBVar01178888
			WBVar01816776
			WBVar01759012
			WBVar00514438
			WBVar00514439
			WBVar01178889
			WBVar00514440
			WBVar01178890
			WBVar01178891
			WBVar00514441
			WBVar00514442
			WBVar01178892
			WBVar00514443
			WBVar01178893
			WBVar00323002
			WBVar01178894
			WBVar00514444
			WBVar00514445
			WBVar01178895
			WBVar00599169
			WBVar00233799
			WBVar01178896
			WBVar00514446
			WBVar00599170
			WBVar00514447
			WBVar01178897
			WBVar00514448
			WBVar00599171
			WBVar01178898
			WBVar00514449
			WBVar00599172
			WBVar01178899
			WBVar00514450
			WBVar01178900
			WBVar02118805
			WBVar00514451
			WBVar01178901
			WBVar01178902
			WBVar00142666
			WBVar00514452
			WBVar01178903
			WBVar00514453
			WBVar01178904
			WBVar00514454
			WBVar00514455
			WBVar01178905
			WBVar01178906
			WBVar00514456
			WBVar00514457
			WBVar02027293
			WBVar01178907
			WBVar00514458
			WBVar02027294
			WBVar01178908
			WBVar02027295
			WBVar00514459
			WBVar01178909
			WBVar00262465
			WBVar01679014
			WBVar01178910
			WBVar00514460
			WBVar01178911
			WBVar00514461
			WBVar01679015
			WBVar01679016
			WBVar00514462
			WBVar01178912
			WBVar01178913
			WBVar01178914
			WBVar01178915
			WBVar01178916
			WBVar00142308
			WBVar01178917
			WBVar01178918
			WBVar01178919
			WBVar01178920
			WBVar01178921
			WBVar01178922
			WBVar02093430
			WBVar01178923
			WBVar01178924
			WBVar01178925
			WBVar01178926
			WBVar02116622
			WBVar01178927
			WBVar01178744
			WBVar01178928
			WBVar01178745
			WBVar01178929
			WBVar01178746
			WBVar01178930
			WBVar01178931
			WBVar01178747
			WBVar01178748
			WBVar01178932
			WBVar01178749
			WBVar01178933
			WBVar01178934
			WBVar01178750
			WBVar01178935
			WBVar01178751
			WBVar01178936
			WBVar01178752
			WBVar01178937
			WBVar01178753
			WBVar02034687
			WBVar01178938
			WBVar01620188
			WBVar01178754
			WBVar01178755
			WBVar02034688
			WBVar01178939
			WBVar01620189
			WBVar00299200
			WBVar01178756
			WBVar01178940
			WBVar01620190
			WBVar02034689
			WBVar01178941
			WBVar01178757
			WBVar02034690
			WBVar01620191
			WBVar01178942
			WBVar01620192
			WBVar01178758
			WBVar01178759
			WBVar01620193
			WBVar01178943
			WBVar01178760
			WBVar00321124
			WBVar01178944
			WBVar01178761
			WBVar01178945
			WBVar01178946
			WBVar01178762
			WBVar01178947
			WBVar01178763
			WBVar01178948
			WBVar01178764
			WBVar02065854
			WBVar01178765
			WBVar02086833
			WBVar01178949
			WBVar02086834
			WBVar01178766
			WBVar02065855
			WBVar01178950
			WBVar01178951
			WBVar01178767
			WBVar00257906
			WBVar02065856
			WBVar01178952
			WBVar02065857
			WBVar01178768
			WBVar01178769
			WBVar02065858
			WBVar01178770
			WBVar02065859
			WBVar00263981
			WBVar02065860
			WBVar01178771
			WBVar02065861
			WBVar01178772
			WBVar01178773
			WBVar02065862
			WBVar01178774
			WBVar01987603
			WBVar02065863
			WBVar01178775
			WBVar01888357
			WBVar01987604
			WBVar02065864
			WBVar01834994
			WBVar01888358
			WBVar02065865
			WBVar01987605
			WBVar01178776
			WBVar01987606
			WBVar02065866
			WBVar01888359
			WBVar01945941
			WBVar01178777
			WBVar02065867
			WBVar01987607
			WBVar01178778
			WBVar01888360
			WBVar01945942
			WBVar01178779
			WBVar01987608
			WBVar01888361
			WBVar01945943
			WBVar01178780
			WBVar01945944
			WBVar01888362
			WBVar01945945
			WBVar01888363
			WBVar01178781
			WBVar01888364
			WBVar01945946
			WBVar01178782
			WBVar01845970
			WBVar01945947
			WBVar01888365
			WBVar01178783
			WBVar01888366
			WBVar01178784
			WBVar01945948
			WBVar01888367
			WBVar01945949
			WBVar01178785
			WBVar01945950
			WBVar01551591
			WBVar01178786
			WBVar01888368
			WBVar01178787
			WBVar01945951
			WBVar01551592
			WBVar01888369
			WBVar01888370
			WBVar01945952
			WBVar01551593
			WBVar01178788
			WBVar01888371
			WBVar01551594
			WBVar01178789
			WBVar01945953
			WBVar01888372
			WBVar01945954
			WBVar01551595
			WBVar01178790
			WBVar01945955
			WBVar01551596
			WBVar01178791
			WBVar01888373
			WBVar01551597
			WBVar01178792
			WBVar01945956
			WBVar01888374
			WBVar01945957
			WBVar02108390
			WBVar01888375
			WBVar01178793
			WBVar01551598
			WBVar01945958
			WBVar01551599
			WBVar01888376
			WBVar01178794
			WBVar01551600
			WBVar01888377
			WBVar00315360
			WBVar01178795
			WBVar01888378
			WBVar01178796
			WBVar01470709
			WBVar01551601
			WBVar01470710
			WBVar01551602
			WBVar01178797
			WBVar01888379
			WBVar02119805
			WBVar01551603
			WBVar01178798
			WBVar01888380
			WBVar01470711
			WBVar01178799
			WBVar01888381
			WBVar01470712
			WBVar01551604
			WBVar01888382
			WBVar01178800
			WBVar01551605
			WBVar00145012
			WBVar01178801
			WBVar01888383
			WBVar01551606
			WBVar01888384
			WBVar01551607
			WBVar01178802
			WBVar00145013
			WBVar01178803
			WBVar01551608
			WBVar01888385
			WBVar00145014
			WBVar01551609
			WBVar01178804
			WBVar00145015
			WBVar01888386
			WBVar01551610
			WBVar01178805
			WBVar01888387
			WBVar00145016
			WBVar01551611
			WBVar01888388
			WBVar01178806
			WBVar00145017
			WBVar00145018
			WBVar01551612
			WBVar01178807
			WBVar00145019
			WBVar01551613
			WBVar01178808
			WBVar01551614
			WBVar01178809
			WBVar00145020
			WBVar01551615
			WBVar01178810
			WBVar00145021
			WBVar00145022
			WBVar01178811
			WBVar01551616
			WBVar00145023
			WBVar01178812
			WBVar00062099
			WBVar01551617
			WBVar01551618
			WBVar01178813
			WBVar00145024
			WBVar01497450
			WBVar01178814
			WBVar01551619
			WBVar00145025
			WBVar00062104
			WBVar01178815
			WBVar00145026
			WBVar01551620
			WBVar00145027
			WBVar01551621
			WBVar01178816
			WBVar00062109
			WBVar01551622
			WBVar00145028
			WBVar01178817
			WBVar01551623
			WBVar01178818
			WBVar01551624
			WBVar01178819
			WBVar01551625
			WBVar01178820
			WBVar01178821
			WBVar01551626
			WBVar00062119
			WBVar01178822
			WBVar01551627
			WBVar00277206
			WBVar01551628
			WBVar02139940
			WBVar01178823
			WBVar01178824
			WBVar01551629
			WBVar02139941
			WBVar00062124
			WBVar02139942
			WBVar01178825
			WBVar01551630
			WBVar01928036
			WBVar01178826
			WBVar02139943
			WBVar01551631
			WBVar01551632
			WBVar01928037
			WBVar01178827
			WBVar02139944
			WBVar02139945
			WBVar01551633
			WBVar00062129
			WBVar01178828
			WBVar01928038
			WBVar01551634
			WBVar01928039
			WBVar01178829
			WBVar01551635
			WBVar01928040
			WBVar01178830
			WBVar02039045
			WBVar00062134
			WBVar01178831
			WBVar01928041
			WBVar01551636
			WBVar01928042
			WBVar01178832
			WBVar01551637
			WBVar01551638
			WBVar01928043
			WBVar01178833
			WBVar00236680
			WBVar01551639
			WBVar01178834
			WBVar00236681
			WBVar00062139
			WBVar01928044
			WBVar01178835
			WBVar01928045
			WBVar00236682
			WBVar01551640
			WBVar01178836
			WBVar01551641
			WBVar02118004
			WBVar01551642
			WBVar01178837
			WBVar00062144
			WBVar01551643
			WBVar00265337
			WBVar01178838
			WBVar01178839
			WBVar01551644
			WBVar01178840
			WBVar01551645
			WBVar01178841
			WBVar00514391
			WBVar01551646
			WBVar00062154
			WBVar01178842
			WBVar00514392
			WBVar01551647
			WBVar01178843
			WBVar01551648
			WBVar00514393
			WBVar01551649
			WBVar01487545
			WBVar01178844
			WBVar00514394
			WBVar01551650
			WBVar01178845
			WBVar00514395
			WBVar00514396
			WBVar01551651
			WBVar01178846
			WBVar01178847
			WBVar00062164
			WBVar00514397
			WBVar01551652
			WBVar01178848
			WBVar00514398
			WBVar01551653
			WBVar01178849
			WBVar00514399
			WBVar01499695
			WBVar01551654
			WBVar01496198
			WBVar00514400
			WBVar01499696
			WBVar01498960
			WBVar01178850
			WBVar00062169
			WBVar01178851
			WBVar00514401
			WBVar00514402
			WBVar01178852
			WBVar00319292
			WBVar01500067
			WBVar00514403
			WBVar00062174
			WBVar01178853
		Legacy_information	e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype).
			See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273
			[Reiner D]] Mac-h (Hyper-ACtivate Muscle)
			[C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT]
		Strain	WBStrain00026762
			WBStrain00026763
			WBStrain00026792
			WBStrain00027002
			WBStrain00004431
			WBStrain00004508
			WBStrain00004193
			WBStrain00006242
			WBStrain00055081
			WBStrain00054759
		RNASeq_FPKM (74)
		GO_annotation (18)
		Ortholog (35)
		Paralog (47)
		Structured_description	Concise_description	unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons.	Paper_evidence	WBPaper00002305
						WBPaper00002665
						WBPaper00004644
						WBPaper00005654
						WBPaper00017138
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	T06H11.1a
			T06H11.1b
			T06H11.1c
			T06H11.1d
			T06H11.1e
			T06H11.1f
			T06H11.1g
		Corresponding_CDS_history	T06H11.1:wp83
		Corresponding_transcript	T06H11.1a.1
			T06H11.1b.1
			T06H11.1c.1
			T06H11.1d.1
			T06H11.1e.1
			T06H11.1f.1
			T06H11.1g.1
		Other_sequence (29)
		Associated_feature (17)
	Experimental_info	RNAi_result (16)
		Expr_pattern	Expr2448
			Expr1020117
			Expr1021035
			Expr1028695
			Expr1032862
			Expr1156295
			Expr1156296
			Expr1156298
			Expr2017890
			Expr2036026
		Drives_construct	WBCnstr00010838
			WBCnstr00030566
			WBCnstr00030567
			WBCnstr00034146
		Construct_product	WBCnstr00010838
			WBCnstr00030566
			WBCnstr00030567
			WBCnstr00034146
		Microarray_results (51)
		Expression_cluster (171)
		Interaction	WBInteraction000028423
			WBInteraction000136892
			WBInteraction000165840
			WBInteraction000200024
			WBInteraction000243038
			WBInteraction000331659
			WBInteraction000418934
			WBInteraction000430959
			WBInteraction000456312
			WBInteraction000585544
	Map_info	Map	X	Position	1.75032	Error	0.007954
		Well_ordered
		Positive	Inside_rearr	stDp2
				nDf19
			Positive_clone	T06H11	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	2_point (15)
			Multi_point	442
				551
				651
				791
				792
				1343
				2260
				2454
				4314
				4494
			Pos_neg_data	272
				497
				942
				656
				661
	Reference (43)
	Remark	The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6)	CGC_data_submission
	Method	Gene