skr-10 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-10 is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-10 is expressed in the tip and end regions of the intestine and can interact in vivo with CUL-1 and CUL-2, C. elegans cullin homologs.
Predicted to enable cullin family protein binding activity. Involved in embryo development; larval development; and post-embryonic body morphogenesis. Acts upstream of or within with a positive effect on mitotic cell cycle. Part of SCF ubiquitin ligase complex. Expressed in intestine. Is an ortholog of human SKP1 (S-phase kinase associated protein 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.