pbs-1 encodes a protease subunit with highest similarity to vertebrate proteasome subunit beta type 6 that affects fertility, embryonic viability, locomotion, and larval viability
Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; autoimmune disease (multiple); and carcinoma (multiple). Is an ortholog of human PSMB9 (proteasome 20S subunit beta 9).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.