WormBase Tree Display for Gene: WBGene00006784

WBGene00006784 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T21C12
  Identity: Version: 1
    Name: CGC_name: unc-49 Person_evidence: WBPerson261
      Sequence_name: T21C12.1
      Molecular_name (40)
      Other_name: unc-49A Accession_evidence: EMBL AF151640
        unc-49B Accession_evidence: EMBL AF151641
        unc-49C Accession_evidence: EMBL AF151644
        CELE_T21C12.1 Accession_evidence: NDB BX284603
      Public_name: unc-49
    DB_info: Database: AceView gene 3L621
        WormQTL gene WBGene00006784
        WormFlux gene WBGene00006784
        NDB locus_tag CELE_T21C12.1
        Panther gene CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3
          family PTHR18945
        NCBI gene 176472
        RefSeq protein (13)
        TrEMBL UniProtAcc (13)
        UniProt_GCRP UniProtAcc G5ECD3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143164
    Allele (220)
    Legacy_information: e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468).
      See also e641, n1324
      [C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT]
    Strain (14)
    Component_of_genotype: WBGenotype00000119
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (37)
    Paralog: WBGene00000042 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000043 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000044 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000045 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000046 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000047 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000048 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000049 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000050 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000051 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000053 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000054 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000055 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000056 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000057 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000058 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000059 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000060 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000061 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000062 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000232 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000233 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000845 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000951 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000955 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001133 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001373 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001512 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001586 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001587 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001588 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001591 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001592 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001593 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002974 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002975 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003386 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006765 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006774 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008551 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00013914 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020836 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017389 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021981 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010994 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007903 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007191 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022283 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006797 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00043066 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017580 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019069 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008997 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011360 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011359 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011358 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013655 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011356 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011355 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020236 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011354 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020048 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015412 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00045385 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00044301 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017543 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017544 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017375 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012857 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013338 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013300 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022247 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013534 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020528 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013517 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020767 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021146 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022106 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010275 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008223 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010741 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008280 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018880 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009799 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020657 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013746 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008076 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008022 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017314 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009790 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020605 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017399 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020569 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012099 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012915 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017483 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044528 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. Paper_evidence: WBPaper00003576
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Aug 2007 00:00:00
      Automated_description: Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1826 Homo sapiens Paper_evidence: WBPaper00060194
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 May 2022 00:00:00
  Models_disease_asserted: WBDOannot00001202
    WBDOannot00001203
  Molecular_info: Corresponding_CDS (13)
    Corresponding_CDS_history: T21C12.1a:wp227
      T21C12.1a:wp239
      T21C12.1g:wp275
    Corresponding_transcript (14)
    Other_sequence (51)
    Associated_feature (25)
  Experimental_info: RNAi_result: WBRNAi00090257 Inferred_automatically: RNAi_primary
      WBRNAi00053708 Inferred_automatically: RNAi_primary
      WBRNAi00089728 Inferred_automatically: RNAi_primary
      WBRNAi00066348 Inferred_automatically: RNAi_primary
      WBRNAi00027895 Inferred_automatically: RNAi_primary
      WBRNAi00000954 Inferred_automatically: RNAi_primary
      WBRNAi00090099 Inferred_automatically: RNAi_primary
      WBRNAi00018961 Inferred_automatically: RNAi_primary
      WBRNAi00089939 Inferred_automatically: RNAi_primary
      WBRNAi00006214 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1283
      Expr15907
      Expr1027570
      Expr1032855
      Expr1157259
      Expr1200291
      Expr2017881
      Expr2036017
      Marker2
      Marker19
    Drives_construct: WBCnstr00001626
      WBCnstr00001627
      WBCnstr00006881
      WBCnstr00010191
      WBCnstr00019381
      WBCnstr00020581
      WBCnstr00034153
      WBCnstr00042588
    Construct_product: WBCnstr00001627
      WBCnstr00006881
      WBCnstr00016180
      WBCnstr00019381
      WBCnstr00020010
      WBCnstr00020581
      WBCnstr00021428
      WBCnstr00034153
    Antibody: WBAntibody00000613
      WBAntibody00001987
    Microarray_results (88)
    Expression_cluster (187)
    Interaction (31)
    WBProcess: WBbiopr:00000010
  Map_info: Map: III Position: 3.35021 Error: 0.089636
    Well_ordered
    Positive: Inside_rearr: nDf40
        mT1
      Positive_clone: T21C12 Person_evidence: WBPerson39
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 73
        86
        589
        3249
      Multi_point: 60
        81
        85
        86
        87
        88
        89
        211
        212
        213
        214
        215
        216
        300
        301
        469
        471
        472
        473
        474
        476
        482
        483
        489
        493
        494
        497
        500
        501
        503
        504
        507
        514
        562
        563
        1246
        1253
        1356
        1811
        1814
        1819
        2196
        2202
        2203
        2204
        2205
        3217
        3223
        3224
        3235
        3237
        4097
        5025
        5626
        5710
      Pos_neg_data: 3242
        3250
        3251
  Reference (138)
  Remark: Sequence connection from [Bamber BA]
  Method: Gene