WormBase Tree Display for Gene: WBGene00000232
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| WBGene00000232 | SMap | S_parent | Sequence | B0207 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | avr-14 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | B0207.12 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | gbr-2 | ||||||||
| Q17369 | Paper_evidence | WBPaper00040392 | |||||||
| CELE_B0207.12 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | avr-14 | ||||||||
| DB_info | Database | AceView | gene | 1G544 | |||||
| WormQTL | gene | WBGene00000232 | |||||||
| WormFlux | gene | WBGene00000232 | |||||||
| NDB | locus_tag | CELE_B0207.12 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000232|UniProtKB=Q95Q97 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 172270 | |||||||
| RefSeq | protein | NM_001383181.1 | |||||||
| NM_001025792.5 | |||||||||
| NM_001392384.1 | |||||||||
| TrEMBL | UniProtAcc | Q95Q97 | |||||||
| Q95Q96 | |||||||||
| Q8IFY7 | |||||||||
| UniProt_GCRP | UniProtAcc | Q95Q97 | |||||||
| OMIM | gene | 138491 | |||||||
| 305990 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | avr | ||||||||
| Allele (72) | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (59) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons. | Paper_evidence | WBPaper00003954 | |||||
| WBPaper00004103 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables extracellularly glutamate-gated chloride channel activity. Involved in several processes, including locomotion involved in locomotory behavior; regulation of pharyngeal pumping; and response to xenobiotic stimulus. Located in membrane. Expressed in head; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||||
| DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||||
| Molecular_info | Corresponding_CDS | B0207.12a | |||||||
| B0207.12b | |||||||||
| B0207.12c | |||||||||
| Corresponding_CDS_history | B0207.12:wp24 | ||||||||
| B0207.12a:wp88 | |||||||||
| Corresponding_transcript | B0207.12a.1 | ||||||||
| B0207.12a.2 | |||||||||
| B0207.12a.3 | |||||||||
| B0207.12b.1 | |||||||||
| B0207.12c.1 | |||||||||
| Other_sequence (46) | |||||||||
| Associated_feature | WBsf664305 | ||||||||
| WBsf983805 | |||||||||
| WBsf983806 | |||||||||
| WBsf983807 | |||||||||
| WBsf983808 | |||||||||
| WBsf983809 | |||||||||
| WBsf1009886 | |||||||||
| WBsf1009887 | |||||||||
| WBsf1009888 | |||||||||
| WBsf219510 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027768 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00002839 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085181 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038715 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085182 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr975 | ||||||||
| Expr9614 | |||||||||
| Expr12405 | |||||||||
| Expr16158 | |||||||||
| Expr1027675 | |||||||||
| Expr1142924 | |||||||||
| Expr1200293 | |||||||||
| Expr2009523 | |||||||||
| Expr2027760 | |||||||||
| Drives_construct | WBCnstr00013830 | ||||||||
| WBCnstr00014175 | |||||||||
| WBCnstr00021672 | |||||||||
| WBCnstr00037642 | |||||||||
| Construct_product | WBCnstr00013830 | ||||||||
| WBCnstr00037642 | |||||||||
| Antibody | WBAntibody00001572 | ||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction (35) | |||||||||
| Map_info | Map | I | Position | 0.500409 | Error | 0.012051 | |||
| Positive | Positive_clone | B0207 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4000 | |||||||
| 4001 | |||||||||
| 4380 | |||||||||
| Reference (54) | |||||||||
| Method | Gene |
