WormBase Tree Display for Gene: WBGene00001591
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| WBGene00001591 | SMap | S_parent | Sequence | F11A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | glc-1 | Person_evidence | WBPerson32 | |||||
| Sequence_name | F11A5.10 | ||||||||
| Molecular_name | F11A5.10 | ||||||||
| F11A5.10.1 | |||||||||
| CE24896 | |||||||||
| Other_name | GluCl alpha | Paper_evidence | WBPaper00005494 | ||||||
| WBPaper00044702 | |||||||||
| CELE_F11A5.10 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | glc-1 | ||||||||
| DB_info | Database | AceView | gene | 5Q701 | |||||
| WormQTL | gene | WBGene00001591 | |||||||
| WormFlux | gene | WBGene00001591 | |||||||
| NDB | locus_tag | CELE_F11A5.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001591|UniProtKB=G5EBR3 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 180086 | |||||||
| RefSeq | protein | NM_074689.7 | |||||||
| SwissProt | UniProtAcc | G5EBR3 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBR3 | |||||||
| OMIM | gene | 138491 | |||||||
| 138492 | |||||||||
| 305990 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glc | ||||||||
| Allele (121) | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (101) | |||||||||
| Structured_description | Concise_description | glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin. | Paper_evidence | WBPaper00002049 | |||||
| WBPaper00003319 | |||||||||
| WBPaper00003954 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Expressed in body wall musculature; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||||
| DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||||
| DOID:0060697 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4329) | ||||||
| Molecular_info | Corresponding_CDS | F11A5.10 | |||||||
| Corresponding_transcript | F11A5.10.1 | ||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf647623 | ||||||||
| WBsf233084 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00044346 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00103267 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085188 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103268 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030804 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066347 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085186 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085187 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013102 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085184 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9953 | ||||||||
| Expr1021950 | |||||||||
| Expr1148282 | |||||||||
| Expr2012079 | |||||||||
| Expr2030315 | |||||||||
| Drives_construct | WBCnstr00009990 | ||||||||
| WBCnstr00009991 | |||||||||
| WBCnstr00009992 | |||||||||
| WBCnstr00009993 | |||||||||
| WBCnstr00009994 | |||||||||
| WBCnstr00009995 | |||||||||
| WBCnstr00009996 | |||||||||
| WBCnstr00014965 | |||||||||
| WBCnstr00036841 | |||||||||
| Construct_product | WBCnstr00009990 | ||||||||
| WBCnstr00009991 | |||||||||
| WBCnstr00009992 | |||||||||
| WBCnstr00009993 | |||||||||
| WBCnstr00009994 | |||||||||
| WBCnstr00009995 | |||||||||
| WBCnstr00009996 | |||||||||
| WBCnstr00014965 | |||||||||
| WBCnstr00036841 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (239) | |||||||||
| Interaction (73) | |||||||||
| Map_info | Map | V | Position | 9.84523 | Error | 0.001681 | |||
| Positive | Positive_clone | F11A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
