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WormBase Tree Display for Gene: WBGene00001591

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Name Class

WBGene00001591SMapS_parentSequenceF11A5
IdentityVersion1
NameCGC_nameglc-1Person_evidenceWBPerson32
Sequence_nameF11A5.10
Molecular_nameF11A5.10
F11A5.10.1
CE24896
Other_nameGluCl alphaPaper_evidenceWBPaper00005494
WBPaper00044702
CELE_F11A5.10Accession_evidenceNDBBX284605
Public_nameglc-1
DB_infoDatabaseAceViewgene5Q701
WormQTLgeneWBGene00001591
WormFluxgeneWBGene00001591
NDBlocus_tagCELE_F11A5.10
PanthergeneCAEEL|WormBase=WBGene00001591|UniProtKB=G5EBR3
familyPTHR18945
NCBIgene180086
RefSeqproteinNM_074689.7
SwissProtUniProtAccG5EBR3
UniProt_GCRPUniProtAccG5EBR3
OMIMgene138491
138492
305990
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classglc
Allele (121)
Strain (12)
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (38)
Paralog (101)
Structured_descriptionConcise_descriptionglc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin.Paper_evidenceWBPaper00002049
WBPaper00003319
WBPaper00003954
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Expressed in body wall musculature; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070422Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4327)
DOID:0060696Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4326)
DOID:0060697Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4329)
Molecular_infoCorresponding_CDSF11A5.10
Corresponding_transcriptF11A5.10.1
Other_sequence (15)
Associated_featureWBsf647623
WBsf233084
Experimental_infoRNAi_resultWBRNAi00044346Inferred_automaticallyRNAi_primary
WBRNAi00103267Inferred_automaticallyRNAi_primary
WBRNAi00085188Inferred_automaticallyRNAi_primary
WBRNAi00103268Inferred_automaticallyRNAi_primary
WBRNAi00030804Inferred_automaticallyRNAi_primary
WBRNAi00066347Inferred_automaticallyRNAi_primary
WBRNAi00085186Inferred_automaticallyRNAi_primary
WBRNAi00085187Inferred_automaticallyRNAi_primary
WBRNAi00013102Inferred_automaticallyRNAi_primary
WBRNAi00085184Inferred_automaticallyRNAi_primary
Expr_patternExpr9953
Expr1021950
Expr1148282
Expr2012079
Expr2030315
Drives_constructWBCnstr00009990
WBCnstr00009991
WBCnstr00009992
WBCnstr00009993
WBCnstr00009994
WBCnstr00009995
WBCnstr00009996
WBCnstr00014965
WBCnstr00036841
Construct_productWBCnstr00009990
WBCnstr00009991
WBCnstr00009992
WBCnstr00009993
WBCnstr00009994
WBCnstr00009995
WBCnstr00009996
WBCnstr00014965
WBCnstr00036841
Microarray_results (20)
Expression_clusterWBPaper00031486:daf-16_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:intestine_larva_enriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00041163:hly(+)-V-cholerae_induced
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-2(RNAi)_upregulated
WBPaper00044030:nhr-8(hd117)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045314:S.aureus-induced_N2
WBPaper00045390:tunicamycin_downregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00046509:lin-35(n745)_upregulated
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_1
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049635:dop-1(vs100)_downregulated
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049920:hyl-2(tm2031)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(+)
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:intestine_enriched
WBPaper00051257:Levamisole_upregulated
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051558:fog-2(q71)_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053154:human-amyloid-beta_tau_regulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot267)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053402:his-3(RNAi)_upregulated
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055897:heat-shock_downregulated
WBPaper00055941:hif-1(ia4)_upregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056039:efa-6(tm3124)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056167:Cry5B_downregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
WBPaper00056586:kri-1(ok1251)_upregulated
WBPaper00056731:human-amylin_upregulated
WBPaper00056826:SGP_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_upregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059605:mut-16(pk710)_downregulated
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060634:fhod-1(tm2363)_upregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060871:M.humicola-extract_4h_regulated
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00060921:tdc-1(n3419)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061341:28C_24h_upregulated
WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
WBPaper00061405:S.aureus_downregulated_starvation
WBPaper00061424:Diet_MYb131_upregulated
WBPaper00061527:T16H12.9-kin-9_20752
WBPaper00061530:nhr-49(e2144)_upregulated
WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
WBPaper00061952:daf-18(nr2037)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062193:daf-16(RNAi)_downregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062446:nhr-8(ok186)_upregulated
WBPaper00062590:Aging_upregulated_intestine
WBPaper00062606:rotenone_upregulated
WBPaper00062715:blmp-1(s71)_upregulated
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00064632:daf-2(e1370)_downregulated_intestine
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065158:AFD_depleted
WBPaper00065746:tmc-1(rg1003)_downregulated
WBPaper00065841:33_0
WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_12
WBPaper00027722:Microbacterium_nematophilum_upregulated
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00028789:PA14_vs_OP50_upregulated_8hr
WBPaper00029437:dcr-1_upregulated
WBPaper00032948:StarveUp3
WBPaper00034739:N2moreDR1350
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036286:Pattern_D
WBPaper00036464:S.aureus-RN6390_regulated
WBPaper00037113:DZN_16C_up-regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040963:Q100_up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041207:CE_dauer_up
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00045865:biofilm_upregulated_A
WBPaper00045960:L4-lethargus_upregulated
WBPaper00047021:MWCNT_downregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053688:E.faecalis_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (73)
Map_infoMapVPosition9.84523Error0.001681
PositivePositive_cloneF11A5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (32)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene