WormBase Tree Display for Gene: WBGene00001591
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WBGene00001591 | SMap | S_parent | Sequence | F11A5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | glc | ||||||
Allele (121) | |||||||
Strain (12) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (38) | |||||||
Paralog (101) | |||||||
Structured_description | Concise_description | glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin. | Paper_evidence | WBPaper00002049 | |||
WBPaper00003319 | |||||||
WBPaper00003954 | |||||||
Curator_confirmed | WBPerson48 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Expressed in body wall musculature; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||
DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||
DOID:0060697 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4329) | ||||
Molecular_info | Corresponding_CDS | F11A5.10 | |||||
Corresponding_transcript | F11A5.10.1 | ||||||
Other_sequence (15) | |||||||
Associated_feature | WBsf647623 | ||||||
WBsf233084 | |||||||
Experimental_info | RNAi_result | WBRNAi00044346 | Inferred_automatically | RNAi_primary | |||
WBRNAi00103267 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085188 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00103268 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030804 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066347 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085186 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085187 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00013102 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085184 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr9953 | ||||||
Expr1021950 | |||||||
Expr1148282 | |||||||
Expr2012079 | |||||||
Expr2030315 | |||||||
Drives_construct | WBCnstr00009990 | ||||||
WBCnstr00009991 | |||||||
WBCnstr00009992 | |||||||
WBCnstr00009993 | |||||||
WBCnstr00009994 | |||||||
WBCnstr00009995 | |||||||
WBCnstr00009996 | |||||||
WBCnstr00014965 | |||||||
WBCnstr00036841 | |||||||
Construct_product | WBCnstr00009990 | ||||||
WBCnstr00009991 | |||||||
WBCnstr00009992 | |||||||
WBCnstr00009993 | |||||||
WBCnstr00009994 | |||||||
WBCnstr00009995 | |||||||
WBCnstr00009996 | |||||||
WBCnstr00014965 | |||||||
WBCnstr00036841 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (239) | |||||||
Interaction (73) | |||||||
Map_info | Map | V | Position | 9.84523 | Error | 0.001681 | |
Positive | Positive_clone | F11A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (32) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |