WormBase Tree Display for Gene: WBGene00000233
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| WBGene00000233 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | avr-15 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | R11G10.1 | ||||||||
| Molecular_name | R11G10.1a | ||||||||
| R11G10.1a.1 | |||||||||
| CE25076 | |||||||||
| R11G10.1b | |||||||||
| CE13573 | |||||||||
| R11G10.1c | |||||||||
| CE45109 | |||||||||
| R11G10.1b.1 | |||||||||
| R11G10.1c.1 | |||||||||
| Other_name | CELE_R11G10.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | avr-15 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | avr | ||||||||
| Allele (310) | |||||||||
| Legacy_information | [Dent JA] >20x synthetic avermectin resistance. Lacks M3 neurotransmission. Slightly starved. Prolonged pharyngeal contractions. Encodes ivermectin-sensitive glutamate-gated chloride channel subunit (?predicted gene T10G3.6). | ||||||||
| ad1051 : Eat phenotype, lacks M3-derived IPSP; isolated pharynx insensitive to iontophoretically applied glutamate.[CD; AD] | |||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (56) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | avr-15 encodes, via alternative splicing, two glutamate-gated chloride channel subunit homologs; these proteins mediate fast inhibitory glutamatergic neuromuscular transmission, as well as ivermectin sensitivity, and are required for normal pharyngeal function. | Paper_evidence | WBPaper00002920 | |||||
| WBPaper00003954 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in action potential; locomotion involved in locomotory behavior; and regulation of pharyngeal pumping. Predicted to be located in neuron projection and synapse. Expressed in motor neurons; pharynx; preanal ganglion neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in hyperekplexia 2 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2); GLRA3 (glycine receptor alpha 3); and GLRB (glycine receptor beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||||
| DOID:0060697 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4329) | ||||||
| Molecular_info | Corresponding_CDS | R11G10.1a | |||||||
| R11G10.1b | |||||||||
| R11G10.1c | |||||||||
| Corresponding_CDS_history | R11G10.1:wp51 | ||||||||
| Corresponding_transcript | R11G10.1a.1 | ||||||||
| R11G10.1b.1 | |||||||||
| R11G10.1c.1 | |||||||||
| Other_sequence (39) | |||||||||
| Associated_feature | WBsf653315 | ||||||||
| WBsf653316 | |||||||||
| WBsf653317 | |||||||||
| WBsf653318 | |||||||||
| WBsf1001831 | |||||||||
| WBsf1001832 | |||||||||
| WBsf1020728 | |||||||||
| WBsf234818 | |||||||||
| WBsf234819 | |||||||||
| WBsf234820 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00018559 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030215 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085183 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017762 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051804 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1454 | ||||||||
| Expr1799 | |||||||||
| Expr13471 | |||||||||
| Expr13480 | |||||||||
| Expr1011432 | |||||||||
| Expr1155465 | |||||||||
| Expr2009524 | |||||||||
| Expr2027761 | |||||||||
| Drives_construct | WBCnstr00004936 | ||||||||
| WBCnstr00010282 | |||||||||
| WBCnstr00010455 | |||||||||
| WBCnstr00015856 | |||||||||
| Construct_product (13) | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (163) | |||||||||
| Interaction (14) | |||||||||
| Map_info | Map | V | Position | 5.39241 | Error | 0.010538 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K10B8 | |||||||
| R11G10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| T10G3 | |||||||||
| Negative | Outside_rearr | yDf8 | |||||||
| Mapping_data | Multi_point | 4176 | |||||||
| Pos_neg_data | 9130 | ||||||||
| Reference (65) | |||||||||
| Remark | T10G3.7 sequence removed, now named R11G10.1 in sequence annotation. [sdm 05/00] | ||||||||
| Method | Gene |
