WormBase Tree Display for Gene: WBGene00000845
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| WBGene00000845 | Evidence | Person_evidence | WBPerson170 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C02C2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cup-4 | Person_evidence | WBPerson170 | |||||
| Sequence_name | C02C2.3 | ||||||||
| Molecular_name | C02C2.3 | ||||||||
| C02C2.3.1 | |||||||||
| CE30416 | |||||||||
| Other_name | CELE_C02C2.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cup-4 | ||||||||
| DB_info | Database | AceView | gene | 3I957 | |||||
| WormQTL | gene | WBGene00000845 | |||||||
| WormFlux | gene | WBGene00000845 | |||||||
| NDB | locus_tag | CELE_C02C2.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000845|UniProtKB=P34271 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 176104 | |||||||
| RefSeq | protein | NM_066309.6 | |||||||
| SwissProt | UniProtAcc | P34271 | |||||||
| UniProt_GCRP | UniProtAcc | P34271 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cup | ||||||||
| Allele (34) | |||||||||
| Strain | WBStrain00031661 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (29) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | cup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles. | Paper_evidence | WBPaper00004883 | |||||
| WBPaper00006324 | |||||||||
| WBPaper00025238 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Sep 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C02C2.3 | |||||||
| Corresponding_transcript | C02C2.3.1 | ||||||||
| Other_sequence | JO468316.1 | ||||||||
| JI169898.1 | |||||||||
| Oden_isotig23439 | |||||||||
| Associated_feature | WBsf645364 | ||||||||
| WBsf225290 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr3280 | ||||||||
| Expr16469 | |||||||||
| Expr1011461 | |||||||||
| Expr1030524 | |||||||||
| Expr1143520 | |||||||||
| Expr1200314 | |||||||||
| Expr2010596 | |||||||||
| Expr2028836 | |||||||||
| Drives_construct | WBCnstr00005671 | ||||||||
| WBCnstr00005672 | |||||||||
| WBCnstr00011282 | |||||||||
| WBCnstr00037250 | |||||||||
| Construct_product | WBCnstr00007433 | ||||||||
| WBCnstr00011282 | |||||||||
| WBCnstr00037250 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction | WBInteraction000051699 | ||||||||
| WBInteraction000390325 | |||||||||
| WBInteraction000421321 | |||||||||
| WBInteraction000585701 | |||||||||
| Map_info | Map | III | Position | -0.533135 | Error | 0.003482 | |||
| Positive | Positive_clone | C02C2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| pJF148 | Person_evidence | WBPerson170 | |||||||
| Mapping_data | Multi_point | 3952 | |||||||
| 5055 | |||||||||
| Reference (13) | |||||||||
| Remark | pJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAi | Person_evidence | WBPerson170 | ||||||
| Method | Gene |
