WormBase Tree Display for Gene: WBGene00001592
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| WBGene00001592 | SMap | S_parent | Sequence | F25F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | glc-2 | Person_evidence | WBPerson32 | |||||
| Sequence_name | F25F8.2 | ||||||||
| Molecular_name | F25F8.2 | ||||||||
| F25F8.2.1 | |||||||||
| CE09636 | |||||||||
| Other_name | avm-2 | ||||||||
| GluCl beta | Paper_evidence | WBPaper00005494 | |||||||
| WBPaper00044702 | |||||||||
| WBPaper00051057 | |||||||||
| CELE_F25F8.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | glc-2 | ||||||||
| DB_info | Database | AceView | gene | 1F454 | |||||
| WormQTL | gene | WBGene00001592 | |||||||
| WormFlux | gene | WBGene00001592 | |||||||
| NDB | locus_tag | CELE_F25F8.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001592|UniProtKB=Q17328 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 172103 | |||||||
| RefSeq | protein | NM_059069.4 | |||||||
| SwissProt | UniProtAcc | Q17328 | |||||||
| UniProt_GCRP | UniProtAcc | Q17328 | |||||||
| OMIM | gene | 138491 | |||||||
| 305990 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glc | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00028915 | ||||||||
| WBStrain00035700 | |||||||||
| WBStrain00036012 | |||||||||
| WBStrain00035006 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (51) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping. | Paper_evidence | WBPaper00002049 | |||||
| WBPaper00002808 | |||||||||
| WBPaper00006139 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables extracellularly glutamate-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. Expressed in pm4. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||||
| DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||||
| Molecular_info | Corresponding_CDS | F25F8.2 | |||||||
| Corresponding_transcript | F25F8.2.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf983527 | ||||||||
| WBsf1009726 | |||||||||
| WBsf219327 | |||||||||
| WBsf219328 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00045520 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00045519 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085185 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003451 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027617 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1471 | ||||||||
| Expr1017586 | |||||||||
| Expr1030954 | |||||||||
| Expr1149437 | |||||||||
| Expr1200289 | |||||||||
| Expr2012080 | |||||||||
| Expr2030316 | |||||||||
| Drives_construct | WBCnstr00036840 | ||||||||
| Construct_product | WBCnstr00036840 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | I | Position | -0.683729 | Error | 0.00921 | |||
| Positive | Positive_clone | F25F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4347 | |||||||
| 4424 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | sequence connection from [Vassilatis DK] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
