WormBase Tree Display for Gene: WBGene00003386
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| WBGene00003386 | Evidence | Paper_evidence | WBPaper00004415 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K06C4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mod-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | K06C4.6 | ||||||||
| Molecular_name | K06C4.6a | ||||||||
| K06C4.6a.1 | |||||||||
| CE28590 | |||||||||
| K06C4.6b | |||||||||
| CE30814 | |||||||||
| K06C4.6c | |||||||||
| CE38391 | |||||||||
| K06C4.6b.1 | |||||||||
| K06C4.6c.1 | |||||||||
| Other_name | CELE_K06C4.6 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | mod-1 | ||||||||
| DB_info | Database | AceView | gene | 5J390 | |||||
| WormQTL | gene | WBGene00003386 | |||||||
| WormFlux | gene | WBGene00003386 | |||||||
| NDB | locus_tag | CELE_K06C4.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003386|UniProtKB=Q9GQ00 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 179269 | |||||||
| RefSeq | protein | NM_001028863.5 | |||||||
| NM_171495.6 | |||||||||
| NM_001028864.4 | |||||||||
| SwissProt | UniProtAcc | Q9GQ00 | |||||||
| TREEFAM | TREEFAM_ID | TF315490 | |||||||
| UniProt_GCRP | UniProtAcc | Q9GQ00 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mod | ||||||||
| Allele (72) | |||||||||
| Legacy_information | [Ranganathan R] modulation of locomotion defective. Resistant to effects of serotonin on locomotion. | ||||||||
| Strain | WBStrain00027365 | ||||||||
| WBStrain00055584 | |||||||||
| WBStrain00055581 | |||||||||
| WBStrain00055576 | |||||||||
| WBStrain00055575 | |||||||||
| WBStrain00055061 | |||||||||
| WBStrain00055570 | |||||||||
| WBStrain00055580 | |||||||||
| WBStrain00055579 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (29) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | mod-1 encodes a serotonin-gated chloride channel; contrary to published literature, MOD-1 activity is NOT required for the enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; subsequent studies have shown that mod-1 mutants (n3034, ok103, nr2043) do not exhibit reduced enhanced slowing and that the behavioral defect of the original isolate and mod-1 chloride channel mutation (n3034) are genetically separable; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord. | Paper_evidence | WBPaper00004415 | |||||
| Person_evidence | WBPerson461 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Oct 2009 00:00:00 | ||||||||
| Automated_description | Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 May 2019 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000683 | ||||||||
| Molecular_info | Corresponding_CDS | K06C4.6a | |||||||
| K06C4.6b | |||||||||
| K06C4.6c | |||||||||
| Corresponding_transcript | K06C4.6a.1 | ||||||||
| K06C4.6b.1 | |||||||||
| K06C4.6c.1 | |||||||||
| Other_sequence | JI466929.1 | ||||||||
| JI169197.1 | |||||||||
| JI478000.1 | |||||||||
| JI468889.1 | |||||||||
| Associated_feature | WBsf669190 | ||||||||
| WBsf1000785 | |||||||||
| WBsf1000786 | |||||||||
| WBsf1020115 | |||||||||
| WBsf1020116 | |||||||||
| WBsf234154 | |||||||||
| WBsf234155 | |||||||||
| WBsf234156 | |||||||||
| WBsf234157 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00034017 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050055 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00007179 | ||||||||
| WBCnstr00010036 | |||||||||
| WBCnstr00015006 | |||||||||
| WBCnstr00015042 | |||||||||
| WBCnstr00015423 | |||||||||
| WBCnstr00015424 | |||||||||
| WBCnstr00018067 | |||||||||
| WBCnstr00018489 | |||||||||
| WBCnstr00020388 | |||||||||
| WBCnstr00036146 | |||||||||
| Construct_product | WBCnstr00007179 | ||||||||
| WBCnstr00007180 | |||||||||
| WBCnstr00015422 | |||||||||
| WBCnstr00020388 | |||||||||
| WBCnstr00036146 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction | WBInteraction000001399 | ||||||||
| WBInteraction000031265 | |||||||||
| WBInteraction000166111 | |||||||||
| WBInteraction000520738 | |||||||||
| WBInteraction000525285 | |||||||||
| Map_info | Map | V | Position | 1.72643 | Error | 0.025158 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C38E12 | |||||||
| K06C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | C31A10 | |||||||
| Mapping_data | Multi_point | 3874 | |||||||
| 3875 | |||||||||
| 3876 | |||||||||
| 3877 | |||||||||
| 3878 | |||||||||
| 3880 | |||||||||
| 3881 | |||||||||
| 3882 | |||||||||
| 3883 | |||||||||
| Reference (108) | |||||||||
| Remark | Positive clone C38E12 is based on stable transformation rescue [030407 ck1] | Person_evidence | WBPerson1388 | ||||||
| Negative clone C31A10 is based on failure to rescue [030407 ck1] | Person_evidence | WBPerson1388 | |||||||
| This mod-1 (cgc4415) is different from the mod-1 published in cgc3363, which is now dmo-1 | Paper_evidence | WBPaper00004415 | |||||||
| WBPaper00003363 | |||||||||
| Method | Gene |
