WormBase Tree Display for Gene: WBGene00003386
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WBGene00003386 | Evidence | Paper_evidence | WBPaper00004415 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K06C4 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | mod-1 | Person_evidence | WBPerson268 | |||||
Sequence_name | K06C4.6 | ||||||||
Molecular_name | K06C4.6a | ||||||||
K06C4.6a.1 | |||||||||
CE28590 | |||||||||
K06C4.6b | |||||||||
CE30814 | |||||||||
K06C4.6c | |||||||||
CE38391 | |||||||||
K06C4.6b.1 | |||||||||
K06C4.6c.1 | |||||||||
Other_name | CELE_K06C4.6 | Accession_evidence | NDB | BX284605 | |||||
Public_name | mod-1 | ||||||||
DB_info | Database | AceView | gene | 5J390 | |||||
WormQTL | gene | WBGene00003386 | |||||||
WormFlux | gene | WBGene00003386 | |||||||
NDB | locus_tag | CELE_K06C4.6 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003386|UniProtKB=Q9GQ00 | |||||||
family | PTHR18945 | ||||||||
NCBI | gene | 179269 | |||||||
RefSeq | protein | NM_001028863.5 | |||||||
NM_171495.6 | |||||||||
NM_001028864.4 | |||||||||
SwissProt | UniProtAcc | Q9GQ00 | |||||||
TREEFAM | TREEFAM_ID | TF315490 | |||||||
UniProt_GCRP | UniProtAcc | Q9GQ00 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mod | ||||||||
Allele (72) | |||||||||
Legacy_information | [Ranganathan R] modulation of locomotion defective. Resistant to effects of serotonin on locomotion. | ||||||||
Strain | WBStrain00027365 | ||||||||
WBStrain00055584 | |||||||||
WBStrain00055581 | |||||||||
WBStrain00055576 | |||||||||
WBStrain00055575 | |||||||||
WBStrain00055061 | |||||||||
WBStrain00055570 | |||||||||
WBStrain00055580 | |||||||||
WBStrain00055579 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (37) | |||||||||
Ortholog (29) | |||||||||
Paralog (100) | |||||||||
Structured_description | Concise_description | mod-1 encodes a serotonin-gated chloride channel; contrary to published literature, MOD-1 activity is NOT required for the enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; subsequent studies have shown that mod-1 mutants (n3034, ok103, nr2043) do not exhibit reduced enhanced slowing and that the behavioral defect of the original isolate and mod-1 chloride channel mutation (n3034) are genetically separable; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord. | Paper_evidence | WBPaper00004415 | |||||
Person_evidence | WBPerson461 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 07 Oct 2009 00:00:00 | ||||||||
Automated_description | Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000683 | ||||||||
Molecular_info | Corresponding_CDS | K06C4.6a | |||||||
K06C4.6b | |||||||||
K06C4.6c | |||||||||
Corresponding_transcript | K06C4.6a.1 | ||||||||
K06C4.6b.1 | |||||||||
K06C4.6c.1 | |||||||||
Other_sequence | JI466929.1 | ||||||||
JI169197.1 | |||||||||
JI478000.1 | |||||||||
JI468889.1 | |||||||||
Associated_feature | WBsf669190 | ||||||||
WBsf1000785 | |||||||||
WBsf1000786 | |||||||||
WBsf1020115 | |||||||||
WBsf1020116 | |||||||||
WBsf234154 | |||||||||
WBsf234155 | |||||||||
WBsf234156 | |||||||||
WBsf234157 | |||||||||
Experimental_info | RNAi_result | WBRNAi00034017 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050055 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00007179 | ||||||||
WBCnstr00010036 | |||||||||
WBCnstr00015006 | |||||||||
WBCnstr00015042 | |||||||||
WBCnstr00015423 | |||||||||
WBCnstr00015424 | |||||||||
WBCnstr00018067 | |||||||||
WBCnstr00018489 | |||||||||
WBCnstr00020388 | |||||||||
WBCnstr00036146 | |||||||||
Construct_product | WBCnstr00007179 | ||||||||
WBCnstr00007180 | |||||||||
WBCnstr00015422 | |||||||||
WBCnstr00020388 | |||||||||
WBCnstr00036146 | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (131) | |||||||||
Interaction | WBInteraction000001399 | ||||||||
WBInteraction000031265 | |||||||||
WBInteraction000166111 | |||||||||
WBInteraction000520738 | |||||||||
WBInteraction000525285 | |||||||||
Map_info | Map | V | Position | 1.72643 | Error | 0.025158 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C38E12 | |||||||
K06C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Negative_clone | C31A10 | |||||||
Mapping_data | Multi_point | 3874 | |||||||
3875 | |||||||||
3876 | |||||||||
3877 | |||||||||
3878 | |||||||||
3880 | |||||||||
3881 | |||||||||
3882 | |||||||||
3883 | |||||||||
Reference | WBPaper00004415 | ||||||||
WBPaper00010185 | |||||||||
WBPaper00010461 | |||||||||
WBPaper00010474 | |||||||||
WBPaper00010733 | |||||||||
WBPaper00010738 | |||||||||
WBPaper00010752 | |||||||||
WBPaper00010848 | |||||||||
WBPaper00010851 | |||||||||
WBPaper00010916 | |||||||||
WBPaper00011118 | |||||||||
WBPaper00019180 | |||||||||
WBPaper00022649 | |||||||||
WBPaper00023561 | |||||||||
WBPaper00023951 | |||||||||
WBPaper00023953 | |||||||||
WBPaper00024232 | |||||||||
WBPaper00024420 | |||||||||
WBPaper00025145 | |||||||||
WBPaper00025350 | |||||||||
WBPaper00025486 | |||||||||
WBPaper00025774 | |||||||||
WBPaper00025928 | |||||||||
WBPaper00026263 | |||||||||
WBPaper00026747 | |||||||||
WBPaper00026948 | |||||||||
WBPaper00027730 | |||||||||
WBPaper00028134 | |||||||||
WBPaper00028135 | |||||||||
WBPaper00028865 | |||||||||
WBPaper00028900 | |||||||||
WBPaper00029012 | |||||||||
WBPaper00029300 | |||||||||
WBPaper00030234 | |||||||||
WBPaper00030368 | |||||||||
WBPaper00030761 | |||||||||
WBPaper00030989 | |||||||||
WBPaper00031241 | |||||||||
WBPaper00031564 | |||||||||
WBPaper00031834 | |||||||||
WBPaper00031915 | |||||||||
WBPaper00032335 | |||||||||
WBPaper00032336 | |||||||||
WBPaper00032742 | |||||||||
WBPaper00032881 | |||||||||
WBPaper00033181 | |||||||||
WBPaper00033406 | |||||||||
WBPaper00034151 | |||||||||
WBPaper00034152 | |||||||||
WBPaper00034156 | |||||||||
WBPaper00034162 | |||||||||
WBPaper00034655 | |||||||||
WBPaper00035082 | |||||||||
WBPaper00035327 | |||||||||
WBPaper00036766 | |||||||||
WBPaper00037260 | |||||||||
WBPaper00037312 | |||||||||
WBPaper00038382 | |||||||||
WBPaper00039260 | |||||||||
WBPaper00039294 | |||||||||
WBPaper00040144 | |||||||||
WBPaper00041038 | |||||||||
WBPaper00041535 | |||||||||
WBPaper00042291 | |||||||||
WBPaper00042584 | |||||||||
WBPaper00043197 | |||||||||
WBPaper00043429 | |||||||||
WBPaper00043434 | |||||||||
WBPaper00043522 | |||||||||
WBPaper00043908 | |||||||||
WBPaper00044094 | |||||||||
WBPaper00044293 | |||||||||
WBPaper00044757 | |||||||||
WBPaper00046292 | |||||||||
WBPaper00047880 | |||||||||
WBPaper00048770 | |||||||||
WBPaper00049202 | |||||||||
WBPaper00051474 | |||||||||
WBPaper00051807 | |||||||||
WBPaper00052506 | |||||||||
WBPaper00052775 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00056790 | |||||||||
WBPaper00058521 | |||||||||
WBPaper00058535 | |||||||||
WBPaper00058840 | |||||||||
WBPaper00058943 | |||||||||
WBPaper00059099 | |||||||||
WBPaper00059878 | |||||||||
WBPaper00060405 | |||||||||
WBPaper00060722 | |||||||||
WBPaper00060806 | |||||||||
WBPaper00060921 | |||||||||
WBPaper00060976 | |||||||||
WBPaper00061589 | |||||||||
WBPaper00062132 | |||||||||
WBPaper00062340 | |||||||||
WBPaper00062422 | |||||||||
WBPaper00062495 | |||||||||
WBPaper00062573 | |||||||||
WBPaper00064144 | |||||||||
WBPaper00064180 | |||||||||
WBPaper00064348 | |||||||||
WBPaper00064365 | |||||||||
WBPaper00064726 | |||||||||
WBPaper00065325 | |||||||||
WBPaper00065366 | |||||||||
WBPaper00066019 | |||||||||
Remark | Positive clone C38E12 is based on stable transformation rescue [030407 ck1] | Person_evidence | WBPerson1388 | ||||||
Negative clone C31A10 is based on failure to rescue [030407 ck1] | Person_evidence | WBPerson1388 | |||||||
This mod-1 (cgc4415) is different from the mod-1 published in cgc3363, which is now dmo-1 | Paper_evidence | WBPaper00004415 | |||||||
WBPaper00003363 | |||||||||
Method | Gene |