WormBase Tree Display for Gene: WBGene00006820

WBGene00006820 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: unc-89 Person_evidence: WBPerson261
      Sequence_name: C09D1.1
      Molecular_name (48)
      Other_name: phm-1
        CELE_C09D1.1 Accession_evidence: NDB BX284601
      Public_name: unc-89
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 21 Dec 2004 16:19:44 WBPerson2970 Event: Acquires_merge: WBGene00043148
      Acquires_merge: WBGene00043148
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00144017
    Allele: WBVar00092384 Inferred_automatically: From strain object: RB1186
      WBVar00248711 Inferred_automatically: From strain object: RW85
      WBVar00144756
      WBVar00000029
      WBVar00054747
      WBVar00248861
      WBVar00248863
      WBVar00055412
      WBVar00055767
      WBVar00248844
      WBVar00062900
      WBVar00248709
      WBVar00248750
      WBVar00630009
      WBVar00630193
      WBVar00331692
      WBVar01301028
      WBVar01281374
      WBVar00630194
      WBVar01494364
      WBVar00331693
      WBVar00630010
      WBVar01281375
      WBVar00331694
      WBVar00630195
      WBVar01281376
      WBVar00630011
      WBVar00331695
      WBVar01281378
      WBVar00630196
      WBVar00630012
      WBVar00043751
      WBVar00331696
      WBVar01281379
      WBVar00630013
      WBVar00630197
      WBVar01493264
      WBVar01281380
      WBVar00630014
      WBVar00331697
      WBVar00630198
      WBVar00630199
      WBVar00630015
      WBVar00043756
      WBVar01281381
      WBVar00331698
      WBVar00630016
      WBVar00630200
      WBVar01281382
      WBVar00331699
      WBVar01489954
      WBVar01281385
      WBVar00630017
      WBVar00630201
      WBVar01301139
      WBVar01894760
      WBVar00331700
      WBVar00630018
      WBVar01894761
      WBVar00630202
      WBVar01281389
      WBVar00331701
      WBVar01281390
      WBVar00630203
      WBVar00630019
      WBVar00331702
      WBVar00630204
      WBVar00331703
      WBVar00630020
      WBVar01281391
      WBVar00630021
      WBVar00630205
      WBVar00331704
      WBVar01281392
      WBVar00043766
      WBVar01281394
      WBVar00331705
      WBVar00630022
      WBVar00630206
      WBVar01281398
      WBVar00331706
      WBVar00630023
      WBVar00630207
      WBVar00630208
      WBVar00043771
      WBVar01281399
      WBVar00331707
      WBVar00630024
      WBVar00331708
      WBVar00630209
      WBVar01281400
      WBVar00630025
      WBVar00630026
      WBVar00331709
      WBVar01281407
      WBVar00630210
      WBVar00043776
      WBVar00630027
      WBVar01281408
      WBVar00331710
      WBVar02095404
      WBVar00630211
      WBVar00331711
      WBVar01281412
      WBVar01655161
      WBVar00630028
      WBVar00630212
      WBVar00043781
      WBVar00630029
      WBVar00331712
      WBVar01281413
      WBVar00630213
      WBVar01281416
      WBVar00331713
      WBVar00630030
      WBVar01301250
      WBVar00630214
      WBVar00630031
      WBVar02127060
      WBVar01281420
      WBVar00630215
      WBVar00331714
      WBVar01281421
      WBVar02127061
      WBVar00630032
      WBVar02078460
      WBVar00331715
      WBVar00630216
      WBVar00043786
      WBVar00630033
      WBVar00331716
      WBVar02127062
      WBVar01281424
      WBVar00630217
      WBVar00630218
      WBVar01417300
      WBVar02127063
      WBVar01993113
      WBVar01281425
      WBVar00331717
      WBVar01902368
      WBVar00043791
      WBVar00630034
      WBVar00331718
      WBVar00065430
      WBVar02127064
      WBVar00630219
      WBVar00630035
      WBVar02127065
      WBVar00630220
      WBVar00331719
      WBVar00630036
      WBVar02127066
      WBVar00630221
      WBVar00331720
      WBVar00043796
      WBVar00630037
      WBVar00630038
      WBVar00630222
      WBVar00331721
      WBVar00630039
      WBVar00630223
      WBVar00331722
      WBVar00630040
      WBVar00331723
      WBVar00630224
      WBVar00630225
      WBVar00331724
      WBVar00142464
      WBVar00630041
      WBVar00043806
      WBVar00092866
      WBVar00331725
      WBVar00630042
      WBVar00630226
      WBVar00630227
      WBVar00331726
      WBVar00092867
      WBVar00630043
      WBVar01417311
      WBVar00331727
      WBVar00630228
      WBVar00630044
      WBVar00043811
      WBVar00331728
      WBVar00630045
      WBVar00630229
      WBVar00630230
      WBVar00331729
      WBVar00630046
      WBVar00152703
      WBVar00152708
      WBVar00630047
      WBVar00331730
      WBVar00630231
      WBVar00630232
      WBVar00331731
      WBVar00630048
      WBVar00152710
      WBVar00331732
      WBVar00630233
      WBVar00152711
      WBVar00630049
      WBVar00331733
      WBVar00152713
      WBVar00630050
      WBVar00630234
      WBVar00043821
      WBVar00630051
      WBVar00152716
      WBVar00630235
      WBVar00331734
      WBVar00152718
      WBVar00630052
      WBVar00630236
      WBVar00331735
      WBVar00152719
      WBVar00630053
      WBVar00630237
      WBVar00331736
      WBVar01417322
      WBVar00630054
      WBVar00152721
      WBVar00630238
      WBVar00331737
      WBVar00043826
      WBVar00630055
      WBVar00331738
      WBVar00630239
      WBVar00275794
      WBVar00152723
      WBVar00331739
      WBVar00152729
      WBVar01532061
      WBVar00630056
      WBVar00630240
      WBVar00630241
      WBVar00331740
      WBVar00152731
      WBVar01491467
      WBVar00043831
      WBVar00630057
      WBVar01532062
      WBVar01532063
      WBVar00331741
      WBVar00630242
      WBVar00630058
      WBVar00152735
      WBVar01532064
      WBVar00152739
      WBVar00331742
      WBVar01704843
      WBVar00630059
      WBVar00630243
      WBVar00043836
      WBVar01532065
      WBVar00630244
      WBVar00152741
      WBVar00331743
      WBVar00630060
      WBVar00331744
      WBVar00630061
      WBVar00630245
      WBVar00152742
      WBVar01826385
      WBVar00331745
      WBVar00630246
      WBVar00630062
      WBVar00152747
      WBVar00630063
      WBVar00630247
      WBVar00043841
      WBVar00331746
      WBVar01826386
      WBVar00630248
      WBVar00630064
      WBVar00331747
      WBVar00630249
      WBVar00331748
      WBVar00630065
      WBVar00630066
      WBVar00331749
      WBVar00630250
      WBVar00331750
      WBVar00630067
      WBVar00630251
      WBVar01640846
      WBVar00331751
      WBVar00630068
      WBVar00630252
      WBVar01640847
      WBVar01301361
      WBVar00254554
      WBVar00331752
      WBVar00630069
      WBVar02083854
      WBVar00043851
      WBVar00630253
      WBVar00630070
      WBVar00331753
      WBVar00254555
      WBVar00630254
      WBVar00630255
      WBVar00331754
      WBVar00630071
      WBVar00630256
      WBVar00331755
      WBVar00254557
      WBVar00630072
      WBVar00331756
      WBVar00630257
      WBVar00630073
      WBVar00630258
      WBVar00331757
      WBVar01956848
      WBVar00630074
      WBVar01417344
      WBVar00630075
      WBVar00331758
      WBVar00043861
      WBVar00630259
      WBVar00630076
      WBVar00630260
      WBVar00331759
      WBVar00630077
      WBVar01846294
      WBVar00630261
      WBVar00331760
      WBVar00043866
      WBVar00630078
      WBVar01846295
      WBVar00630262
      WBVar00331761
      WBVar00331762
      WBVar00630263
      WBVar01489649
      WBVar00630079
      WBVar00630080
      WBVar00630264
      WBVar00331763
      WBVar00629896
      WBVar00630081
      WBVar00331764
      WBVar00630265
      WBVar00043871
      WBVar00629897
      WBVar00331765
      WBVar00630266
      WBVar00597728
      WBVar00629898
      WBVar00630082
      WBVar00630267
      WBVar00331766
      WBVar00597729
      WBVar00629899
      WBVar00630083
      WBVar00043876
      WBVar00597730
      WBVar00629900
      WBVar00630268
      WBVar00630084
      WBVar00331767
      WBVar00629901
      WBVar01417355
      WBVar00630269
      WBVar00331768
      WBVar00630085
      WBVar00629902
      WBVar00331769
      WBVar00630086
      WBVar00043881
      WBVar00236226
      WBVar00306120
      WBVar00630270
      WBVar02147400
      WBVar00236227
      WBVar00306121
      WBVar00630087
      WBVar00629903
      WBVar00331770
      WBVar00630271
      WBVar00630088
      WBVar00629904
      WBVar00296890
      WBVar00331771
      WBVar00630272
      WBVar00630273
      WBVar00236229
      WBVar00630089
      WBVar00331772
      WBVar00629905
      WBVar00630274
      WBVar00236230
      WBVar01492052
      WBVar00630090
      WBVar00331773
      WBVar00629906
      WBVar00630275
      WBVar00630091
      WBVar00629907
      WBVar01301472
      WBVar00331774
      WBVar00331775
      WBVar00630092
      WBVar00630276
      WBVar00629908
      WBVar00331776
      WBVar00249781
      WBVar00630277
      WBVar00630093
      WBVar00629909
      WBVar00630094
      WBVar00331777
      WBVar00630278
      WBVar00629910
      WBVar00630095
      WBVar00331778
      WBVar00630279
      WBVar00629911
      WBVar01499786
      WBVar00331779
      WBVar00629912
      WBVar00630096
      WBVar00630280
      WBVar00331780
      WBVar00630281
      WBVar02145285
      WBVar00629913
      WBVar00630097
      WBVar00331781
      WBVar00630282
      WBVar00629914
      WBVar00630098
      WBVar00065785
      WBVar00331782
      WBVar00630283
      WBVar00629915
      WBVar00630099
      WBVar00629916
      WBVar00630284
      WBVar00331783
      WBVar00630100
      WBVar00629917
      WBVar00630101
      WBVar00630285
      WBVar00331784
      WBVar01932250
      WBVar00629918
      WBVar00630102
      WBVar00331785
      WBVar00630286
      WBVar01932253
      WBVar00629919
      WBVar00630103
      WBVar00331786
      WBVar00630287
      WBVar00630288
      WBVar00331787
      WBVar00630104
      WBVar00629920
      WBVar02052732
      WBVar01932254
      WBVar00630289
      WBVar01417378
      WBVar00629921
      WBVar00630105
      WBVar00331788
      WBVar01932255
      WBVar01932256
      WBVar00630291
      WBVar00629922
      WBVar00331789
      WBVar00630106
      WBVar00630107
      WBVar00331790
      WBVar00630292
      WBVar01943146
      WBVar00629923
      WBVar01932257
      WBVar00331791
      WBVar00630293
      WBVar01932258
      WBVar00630108
      WBVar00629924
      WBVar01398905
      WBVar00331792
      WBVar00630294
      WBVar00630109
      WBVar01932260
      WBVar00629925
      WBVar00629926
      WBVar01932262
      WBVar01398906
      WBVar00331793
      WBVar01499985
      WBVar00630110
      WBVar00051667
      WBVar00630295
      WBVar00629927
      WBVar00630111
      WBVar00536450
      WBVar01398907
      WBVar01932264
      WBVar00331794
      WBVar00043606
      WBVar00630296
      WBVar01932266
      WBVar00629928
      WBVar01398908
      WBVar00331795
      WBVar00630297
      WBVar00630112
      WBVar00630298
      WBVar00043611
      WBVar00629929
      WBVar00630113
      WBVar00331796
      WBVar01932267
      WBVar00630299
      WBVar00630114
      WBVar00629930
      WBVar02014161
      WBVar02028463
      WBVar00331797
      WBVar00629931
      WBVar00331798
      WBVar00630300
      WBVar00262699
      WBVar00630115
      WBVar01300139
      WBVar00629932
      WBVar00630116
      WBVar00331799
      WBVar00043616
      WBVar00331800
      WBVar00630117
      WBVar00629933
      WBVar00331801
      WBVar00630118
      WBVar00629934
      WBVar00629935
      WBVar00331802
      WBVar00043621
      WBVar00630119
      WBVar00331803
      WBVar00629936
      WBVar00630120
      WBVar00331804
      WBVar00630121
      WBVar00629937
      WBVar00630122
      WBVar00629938
      WBVar00331805
      WBVar00043626
      WBVar00630123
      WBVar00331806
      WBVar00629939
      WBVar01694749
      WBVar00629940
      WBVar02072757
      WBVar00331807
      WBVar00630124
      WBVar02055537
      WBVar01300250
      WBVar00043631
      WBVar00629941
      WBVar00630125
      WBVar00331808
      WBVar00630126
      WBVar00331809
      WBVar00629942
      WBVar00629943
      WBVar00630127
      WBVar00043636
      WBVar00629944
      WBVar00630128
      WBVar01300361
      WBVar00630129
      WBVar00629945
      WBVar00629946
      WBVar00630130
      WBVar00629947
      WBVar00630131
      WBVar00629948
      WBVar00630132
      WBVar00630133
      WBVar00629949
      WBVar01431281
      WBVar00630134
      WBVar00043646
      WBVar00629950
      WBVar00630135
      WBVar01431283
      WBVar00629951
      WBVar01431288
      WBVar00630136
      WBVar00629952
      WBVar01300472
      WBVar01475355
      WBVar01431290
      WBVar00630137
      WBVar00629953
      WBVar00043651
      WBVar00629954
      WBVar01431291
      WBVar01475356
      WBVar00630138
      WBVar00629955
      WBVar00630139
      WBVar01475357
      WBVar00098656
      WBVar01431292
      WBVar00043656
      WBVar00098657
      WBVar00629956
      WBVar00630140
      WBVar00098658
      WBVar00630141
      WBVar00629957
      WBVar00098659
      WBVar00630142
      WBVar00629958
      WBVar00304914
      WBVar00630143
      WBVar00043661
      WBVar00629959
      WBVar00629960
      WBVar00630144
      WBVar00098661
      WBVar00629961
      WBVar00630145
      WBVar00098662
      WBVar00043666
      WBVar00629962
      WBVar00098663
      WBVar00630146
      WBVar00098664
      WBVar00629963
      WBVar00630147
      WBVar00144017
      WBVar02114296
      WBVar00630148
      WBVar00629964
      WBVar00098665
      WBVar00043671
      WBVar01911534
      WBVar00629965
      WBVar00098666
      WBVar00630149
      WBVar00629966
      WBVar00098667
      WBVar01911535
      WBVar00630150
      WBVar00629967
      WBVar01343207
      WBVar00630151
      WBVar00629968
      WBVar00630152
      WBVar00043676
      WBVar01411464
      WBVar00630153
      WBVar00629969
      WBVar00630154
      WBVar00629970
      WBVar01411465
      WBVar00630155
      WBVar00629971
      WBVar00043681
      WBVar01300584
      WBVar01411467
      WBVar01788683
      WBVar01343254
      WBVar00629972
      WBVar00630156
      WBVar01411471
      WBVar00629973
      WBVar00630157
      WBVar01411473
      WBVar00630158
      WBVar00629974
      WBVar00043686
      WBVar00629975
      WBVar00630159
      WBVar01411474
      WBVar00629976
      WBVar00630160
      WBVar00629977
      WBVar00630161
      WBVar00043691
      WBVar00630162
      WBVar00629978
      WBVar01300695
      WBVar00629979
      WBVar00630163
      WBVar00629980
      WBVar02039525
      WBVar01573958
      WBVar00630164
      WBVar00043696
      WBVar02039526
      WBVar01712889
      WBVar00630165
      WBVar00629981
      WBVar02039527
      WBVar00314336
      WBVar00629982
      WBVar01712890
      WBVar00630166
      WBVar00629983
      WBVar00630167
      WBVar01712891
      WBVar02039529
      WBVar00043701
      WBVar00630168
      WBVar00629984
      WBVar02039530
      WBVar00629985
      WBVar00630169
      WBVar00043706
      WBVar00629986
      WBVar00630170
      WBVar00260179
      WBVar00629987
      WBVar00630171
      WBVar01300806
      WBVar00629988
      WBVar00266976
      WBVar00630172
      WBVar00043711
      WBVar00266977
      WBVar00630173
      WBVar00629989
      WBVar00629990
      WBVar00630174
      WBVar00266979
      WBVar00266981
      WBVar00233555
      WBVar00629991
      WBVar00630175
      WBVar00243152
      WBVar01281344
      WBVar00630176
      WBVar00233556
      WBVar00629992
      WBVar00043716
      WBVar00266982
      WBVar00266983
      WBVar00630177
      WBVar00629993
      WBVar01281345
      WBVar00233557
      WBVar00630178
      WBVar01281346
      WBVar00629994
      WBVar00630179
      WBVar00043721
      WBVar01281347
      WBVar00629995
      WBVar00233559
      WBVar00629996
      WBVar00233560
      WBVar00630180
      WBVar01281348
      WBVar00630181
      WBVar00629997
      WBVar01281352
      WBVar00233561
      WBVar00629998
      WBVar01281354
      WBVar00630182
      WBVar00233562
      WBVar01300917
      WBVar01491777
      WBVar01281355
      WBVar00630183
      WBVar01898095
      WBVar00629999
      WBVar01281356
      WBVar00630184
      WBVar00630000
      WBVar01281357
      WBVar00630001
      WBVar00630185
      WBVar01281358
      WBVar00630186
      WBVar00630002
      WBVar00630003
      WBVar00630187
      WBVar00331686
      WBVar01281359
      WBVar01622858
      WBVar01498959
      WBVar00331687
      WBVar00630188
      WBVar00630004
      WBVar01281364
      WBVar00331688
      WBVar00630189
      WBVar00630005
      WBVar01281365
      WBVar00630190
      WBVar00630006
      WBVar00331689
      WBVar00630191
      WBVar00630007
      WBVar00043741
      WBVar01281366
      WBVar00331690
      WBVar01281372
      WBVar00331691
      WBVar00630008
      WBVar00630192
    Legacy_information: e1460 : good movement slightly small thin and transparent; abnormal reduced birefringence in body wall and pharyngeal muscle; thick filaments disarranged no M-line. ES1 ME3. NA > 10 (st85amber r291 etc.).
      [Leon Avery] Pharyngeal contractions are feeble. Worms are small and starved.
      See also ad539, e1460, e2338
      [C.elegansII] e1460 : good movement, slightly small, thin and transparent; abnormal reduced birefringence in body wall and pharyngeal muscle; thick filaments disarranged, no M-line. ES1 ME3. OA>10: st85amb, r291,ad539 (pka phm-1, worms small and starved, feeble pharyngeal contractions), e2338amb,st515::Tc1 etc. Cloned: encodes 750 kD protein related to UNC-22 (twitchin). Antibodies stain middle of A bands. [Waterston et al. 1980; GB]
    Strain: WBStrain00002024
      WBStrain00002131
      WBStrain00031887
      WBStrain00033489
      WBStrain00036403
      WBStrain00036411
      WBStrain00004337
    RNASeq_FPKM (74)
    GO_annotation (49)
    Ortholog (56)
    Paralog: WBGene00001000 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001863 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004130 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006436 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006759 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011880 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017657 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019727 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-89 encodes several protein isoforms variably characterized by the presence or absence of SH3, DH, PH, immunoglobulin and myosin light chain kinase (MLCK)-like protein kinase domains; during development, unc-89 is required for proper organization of A bands in striated muscle and thus for fully normal locomotion, pharyngeal muscle contractions, and body size; unc-89 is expressed in body wall muscle, pharyngeal muscle and some cells in the tail; UNC-89 protein isoforms localize to the middle of A-bands, consistent with UNC-89 being an M line component; UNC-89 interacts with the SCPL-1 phosphatase both in vitro and in vivo. Paper_evidence: WBPaper00002411
            WBPaper00024436
            WBPaper00031595
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Dec 2011 00:00:00
      Automated_description: Enables MATH domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including myofibril assembly; pharyngeal gland morphogenesis; and regulation of striated muscle contraction. Located in M band. Expressed in alimentary muscle; gonad; tail; and vulval muscle. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Is an ortholog of human SPEG (striated muscle enriched protein kinase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111222 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16901)
  Molecular_info: Corresponding_CDS (16)
    Corresponding_CDS_history: C09D1.1g:wp261
    Corresponding_transcript (16)
    Other_sequence (139)
    Associated_feature (48)
  Experimental_info: RNAi_result (25)
    Expr_pattern (15)
    Drives_construct: WBCnstr00002806
      WBCnstr00002896
      WBCnstr00011122
    Construct_product: WBCnstr00011122
      WBCnstr00022809
      WBCnstr00022810
    Antibody: WBAntibody00000105
      WBAntibody00000106
      WBAntibody00000758
      WBAntibody00000759
    Microarray_results (68)
    Expression_cluster (231)
    Interaction (87)
    WBProcess: WBbiopr:00000006
  Map_info: Map: I Position: -1.73264 Error: 0.009136
    Well_ordered
    Positive: Inside_rearr: sDf4
      Positive_clone: C09D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point (15)
      Pos_neg_data: 506
        6165
        6270
        6339
        4746
        3932
        3933
        4559
        5704
  Reference (90)
  Method: Gene