nhr-91 encodes a conserved nuclear receptor that is orthologous to members of the NR6 subfamily of nuclear receptors that includes Drosophila HR4 and human germ cell nuclear factor (GCNF, OMIM:600281, human and mouse GCNF are expressed primarily in the testis); by homology, NHR-91 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-91 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-91 in C. elegans development and/or behavior is not yet known; nhr-91 is expressed in anterior neurons, seam cells, excretory cells, the spermatheca, and the developing vulva.
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in anterior ganglion; excretory cell; seam cell; spermatheca; and vulva. Is an ortholog of human NR6A1 (nuclear receptor subfamily 6 group A member 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.